[精品]放化療聯(lián)合唑來膦酸治療肺癌骨轉(zhuǎn)移臨床觀察

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1、放化療聯(lián)合卩坐來麟酸治療肺癌骨轉(zhuǎn)移臨床觀察【中圖分類號(hào)1R734.2【文獻(xiàn)標(biāo)識(shí)碼】A【文章編號(hào)11672-3873(2011)03-0361-02【摘?！磕康模河^察放化療聯(lián)合醴來麟酸治療肺癌骨轉(zhuǎn)移癌疼痛的療效及對(duì)生存質(zhì)量的影響。方法：分析我院2007年1月一2010年5月收治的54例采用放化療聯(lián)合哩來牒酸治療肺癌骨轉(zhuǎn)移患者的臨床及隨訪資料?；颊呔邮芰司植抗寝D(zhuǎn)移灶30Gy/10fx放療，4周期聯(lián)合鉗類藥物方案的化療及2周期醴來麟酸治療。結(jié)果：疼痛緩解率：完全緩解(CR)：48•15%(26/54),部分緩解(PR)35•19%(19/54)

2、,輕度緩解(MR)：9•26%(5/54),無效(NR)：7•41%(4/54)，總有效率(CR+PR)為83•33%(45/54)。骨轉(zhuǎn)移灶控制率：完全緩解(CR)：1108226;11%(6/54),PR(部分緩解):31•48%(17/54),NC(無效):38•89%(21/54),PD(進(jìn)展):20•37%(11/54)總有效率(CR+PR)為42•60%(23/54)o治療結(jié)束后2個(gè)月活動(dòng)能力改善情況:顯效:29•63%(16/54),有效:59•

3、;26%(32/54),無效：11•11%(6/54),總有效率：88•89%(48/54)。結(jié)論：放化療聯(lián)合呼來麟酸是治療乳腺癌骨轉(zhuǎn)移的一較為理想的治療方案。【關(guān)鍵詞】肺癌/骨轉(zhuǎn)移;放化療/I坐萊麟酸;疼痛緩解率ClinicalobservationofchemoradiotherapycombinedwithzoledronicacidforthepatientswithbonemetastasisinlungcancerNIYu-feng,LIAOZhi-jun,DepartmentofOncolog,ChongmingCenterH

4、ospital,Shanghai202150,China[Abstract]Objective:Toobservetheeffectsandtheinflueneeonlifequalityofchemoradiotherapycombinedwithzoledronicacidinthetreatmentofbonemetastasisoflungcancer?Methods:FromJan2007toMay2010,54patientswithbonemetastasisinlungcancerwereanalyzed•A11patientswer

5、egivenradiotherap(30Gy/lOfx)forlocalbonemetastases,and4cycleplatinum-basedchemotherapyand2cyclezoledronicacid?Results:Thepainreliefrate:completeresponse(CR)was48•15%(26/54),partialresponse(PR)was35•19%(19/54),minorresponse(MR)was9•26%(5/54)andnoresponse(NR)was7•

6、;41%(4/54);Controlratesofbonemetastases:theoverallresponsewas42•60%,CRwas11•11%(6/54),PRwas31•48%(17/54)andNCwas42•60%(23/54),development(PD)was20•37%(11/54);Activitiesimproveafterendingthetreatmentin2months:theoverallresponsewas88•89%(48/54)andCRwa

7、s16case(29•63%),PRwas32cases(59•26%)andNRwas6cases仃1•11%)?Conclusions:ChemoradiotherapycombinedwithzoledronicacidisaneffectivetreatmentforPatientswithbonemetastasesinlungcancer?[Keywords]lungcancer/bonemetastases;chemoradiotherapy/Zoledronicacid;painreliefrates肺癌是當(dāng)今世

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