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1、子癇前期孕婦脂質(zhì)運(yùn)載蛋白2的表達(dá)及意義【摘要】目的:探討脂質(zhì)運(yùn)載蛋白2與子癇前期孕婦發(fā)病的關(guān)系。方法:選取本院2012年1月-2014年1月收治的82例子癇前期孕婦作為研究對象,根據(jù)病情嚴(yán)重程度分為輕度子癇前期組32例和重度子癇前期組50例。選擇同期正常孕婦30例作為對照組,檢測三組孕婦脂質(zhì)運(yùn)載蛋白2水平及內(nèi)皮素水平。結(jié)果:重度子癇前期組的脂質(zhì)運(yùn)載蛋白2濃度為(73.98±15.68)ng/mL,明顯高于輕度子癇前期組的(52.01±13.26)ng/mL,輕、重度子癇前期的脂質(zhì)運(yùn)載蛋白2濃度均明顯高于
2、對照組的(23.11±7.27)ng/mL,且兩組的內(nèi)皮素水平均明顯高于對照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:脂質(zhì)運(yùn)載蛋白2與子癇前期的發(fā)病有密切關(guān)系,并隨病情加重而增高?!娟P(guān)鍵詞】脂質(zhì)運(yùn)載蛋白2;子癇前期;孕婦ExpressionandSignificanceofSerumLipocalin-2inMaternalwithPreec1ampsia/BAIYing,LUQun,LIQiao-ping.//MedicalInnovationofChina,2015,12(26):046-047[
3、Abstract]Objective:Toinvestigatetheassociationbetweenserum1ipocalin-2且ndthepathogenesisofpreeclanpsia.Method:82pregnantwomenwithpreeclampsiaadmittedtoourhospitalfromJanuary2012toJanuary2014wereselectedasresearchobjects,andtheyweredividedintothemildpreecl
4、ampsiagroupfor32casesandtheseverepreeclampsiagroupfor50casesaccordingtotheseverityofthedisease,inthesameperiod,30pregnantwomenwereselectedasthecontrolgroup.Theserumlipocalin-2andendothelinlevelweredetectedintheabovethreegroups.ResuIt:Theserumlipocalin-2l
5、evelintheseverepreeclampsiagroupwas(73?98±15.68)ng/mL,whichwassignificantlyhigherthan(52.01±13.26)ng/niLofthemildpreeclampsiagroup,allofthemweresignificantlyhigherthan(23.11±7.27)ng/mLinthecontrolgroup.Theendothelin1evelsinthetwogroupsweresignificantlyhi
6、gherthanthecontrolgroup,thedifferenceswerestatisticallysignificant.(P0.05).Conelusion:Serumlipocalin-2inmaternalwithpreeclampsiaisassociatedwiththepathogenesisofpreeclampsia,andincreasedwiththeseverityofillness?[Keywords]Lipocalin-2;卩reeclampsia;卩regnant
7、womenFirst-author,saddress:BaoanDistrictMaternalandChildHealthHospitalofShenzhenCity,Shenzhen518101,Chinadoi:10.3969/j.issn.1674-4985.2015.26.014子癇前期發(fā)病機(jī)制與血管內(nèi)皮損傷、炎癥和胰島素抵抗有關(guān)[1]。脂質(zhì)運(yùn)載蛋白2是新發(fā)現(xiàn)的脂肪因子,與炎癥和多種腫瘤的發(fā)生有關(guān)[2-3]o為探討脂質(zhì)運(yùn)載蛋白2在子癇前期發(fā)病過程屮的作用,本文對子癇前期孕婦血清中的脂質(zhì)運(yùn)載蛋白
8、2進(jìn)行檢測,并對檢測結(jié)果進(jìn)行分析。1資料與方法1.1一般資料選擇本院2012年1月-2014年1月收治的82例子癇前期孕婦,根據(jù)病情嚴(yán)重程度分為輕度子癇前期組32例和重度子癇前期組50例。輕度子癇前期組32例孕婦中,年齡23~39歲,平均(31.76±3.57)歲;平均孕周(36.45±3.19)周;重度子癇前期組50例孕婦中,年齡24?38歲,平均(31.89±3.67)歲;平均孕周(36.27土3.22)周。選取同期正常晚期妊娠孕婦30