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1、骨肽聯(lián)合葡萄糖酸鈣治療骨質(zhì)疏松癥的臨床觀察［摘要］目的探討骨肽聯(lián)合葡萄糖酸鈣治療骨質(zhì)疏松癥的臨床效果。方法選擇2013年1~11月本院收治的120例骨質(zhì)疏松癥患者為研究對(duì)象,隨機(jī)分為觀察組和治療組各60例，對(duì)照組患者給予非笛體消炎鎮(zhèn)痛藥物和鈣劑口服，同時(shí)給予補(bǔ)充維生索D。觀察組患者在對(duì)照組治療基礎(chǔ)上給予骨肽(50mg)+250ml0.9%NaCl注射液以及葡萄糖酸鈣(10%,20ml)+250ml5%葡萄糖注射液靜脈滴注，治療2個(gè)月后觀察比較兩組患者的骨痛改善情況、腰椎和左側(cè)股骨頸骨密度的變化情況。結(jié)果觀
2、察組患者治療總有效率(90.00%)明顯高于對(duì)照組(56.67%),差異有統(tǒng)計(jì)學(xué)意義(P<0.05)；觀察組治療后腰椎L2~4骨密度水平為(0?78土0?10)g/cm2,左側(cè)股骨頸骨密度水平為(0?58±0?02)g/ciTi2,均明顯高于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義(P<0.05)；兩組不良反應(yīng)發(fā)生率差異無統(tǒng)計(jì)學(xué)意義(P>0.05)o結(jié)論骨肽聯(lián)合葡萄糖酸鈣治療骨質(zhì)疏松癥效果較好，能有效改善骨痛，提高骨密度，值得臨床推廣應(yīng)用。［關(guān)鍵詞］骨肽；葡萄糖酸鈣；骨質(zhì)疏松癥［中圖分類號(hào)］R681E文獻(xiàn)標(biāo)識(shí)碼］A［文章
3、編號(hào)］1674-4721(2014)05(b)-0085-03ClinicalobservationofthebonepeptidejointcalciumgluconateintreatmentofosteoporosisMOZu-shuangTheFirstDepartmentofInternalMedicine,People^sHospitalofXingyeCountyinGuangxiZhuangAutonomousRegion,Xingye537800,China[Abstract]Objec
4、tiveToinvestigatetheclinicaleffectofbonepeptidejointcalciumgluconateinthetreatmentofosteoporosis.Methods120casesofpatientswithosteoporosisinourhospitalfromJanuarytoNovember2013weredividedintocontrolgroup(60cases)andobservationgroup(60cases),thecontrolgrou
5、pweretreatedbynon一steroidalanti一inf1animatorydrugs,oralcalciumandvitaminDsupplements;theobservationgroupweretreatedbyossotide(50mg)+250ml0.9%NaClandcalciumgluconateinjection(10%,20ml)+250ml5%glucoseintravenousinjectiononthebasisofcontrolgroup?Theimproveme
6、ntofbonepain,lumbarspineandleftfemoralneckbonemineraldensitychangesincircumstancesoftwogroupswereanalyzed.ResultsThetotaleffectiverateoftheobservationgroup(90.00%)wassignificantlyhigherthanthatofthecontrolgroup(56.67%),thedifferencewassignificnat(P<0?05).
7、Bonemineraldensityofthe1umbarspineL2~4levelswas(0.78+0.10)g/cm2andtheleftfemoralneckbonemineraldensitylevelswas(0.58+0.02)g/cm2oftheobservationgroup,whichwasrespectively,thedifferencewassignificnat(P<0.05).Adversereactionrateofthetwogroupshadnosignificant
8、difference(P>0.05)?ConclusionTheefficacyofbonepeptidejointcalciumgluconatetreatingosteoporosisiswell,itcaneffectivelyimprovebonepainandincreasebonemineraldensity,isworthusinginclinic?［Keywords］Bonepeptide;Calciumglu
