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1、12王洪靜周雪艷(1.大慶龍南醫(yī)院干部病房,黑龍江大慶1634532.吉林大學(xué)中日聯(lián)誼醫(yī)院心內(nèi)科,吉林長春130031)[摘要]目的:探討應(yīng)用血管緊張素轉(zhuǎn)換酶抑制劑治療房顫的臨床意義;方法:60例房顫患者隨機(jī)分為2組,1組常規(guī)治療設(shè)為對照組,1組在給予常規(guī)治療的基礎(chǔ)上加用ACET類藥物(洛汀新)設(shè)為治療組,觀測兩組房顫患者的轉(zhuǎn)復(fù)成功率、房顫復(fù)發(fā)率、左心功能EF%、左房大小,血管緊張素II水平(Angll),心電圖ST段改變,隨訪6個(gè)月,結(jié)果:治療組較對照組Angll濃度降低,房顫轉(zhuǎn)復(fù)成功率高,復(fù)發(fā)率低、左心房縮小,半年后發(fā)生心功能不全的比例均較對
2、照組低。結(jié)論:房顫患者早期應(yīng)用血管緊張素轉(zhuǎn)換酶抑制劑,可能改善房顫的轉(zhuǎn)律效果及抑制心房重構(gòu),改善心功能。[關(guān)鍵詞]心房顫動(dòng)腎素-血管緊張素-醛固酮系統(tǒng)血管緊張素轉(zhuǎn)換酶抑制劑鹽酸貝那普利[中圖分類號]R541.75[文獻(xiàn)標(biāo)識碼]BTheclinicalresearchofBenazeprilhydrochloride(1otensin)totreatatrialfibrillationWANGHong-jing1,ZHOUXue-yan2(1.DepartmentofCadreWard,Longnanhospitai,Daqingl63453,Ch
3、ina;2.DepartmentofCardiovascula-rChina-JapanUnionHospital,JilinUniversity,Changchun130031,China)Abstract:ObjectiveTodiscussvasculartensionpigmentconversionenzymeinhibitortreatmentatrialfibrillationofclinicalsignificance?Method:60casesatrialfibrillationpatientsrandomisdividedi
4、nto2group,1GroupGeneraltreatmentsetforcontrolledgroup,1groupinregulartreatmentonthebasisoftheadditionalapplicationofACEIdrug(lotensin)issettothetreatmentgroup,observationtwogroupatrialfibril!ationpatientsofcardioversionsuccessrate,andatrialfibri1lationrecurrencerate,andlefthe
5、artfunctionEF%,andleftatrialsize,vasculartensionpigmentII1evel(AnglI),ECGSTsegmentchange,follow-up6months?ResuIts:TreatmentgroupcomparedwithcontrolgroupsAnglIconcentrationreduced,atrialfibri1lationcardioversionsuccessrateishigh,lowrecurrencerate,Leftatriallessen,sixmonthsafte
6、rcardiacinsufficiencyoftheratioislowerthanthecontrolgroup?Conclusion:Atrialfibril1ationinpatientswithearlyuseofangiotensin-conveTtingenzymeinhibitor,mayimprovethetransferlegaleffectandsuppressionofatrialfibri1lationatrialremodeling,improvingcardiacfunction.KeyWord:Atrialfibri
7、llationjrenin-angiotensin-aldosteronesystem;angiotensin-convertingenzymeinhibitors;Benazeprilhydrochloride心房顫動(dòng)(atrialfibrillation,AF)是臨床上最常見的心律失常,但有關(guān)房顫的發(fā)生機(jī)制至今尚未闡明。隨著研究的深入,越來越多的證據(jù)表明心房電重構(gòu)和結(jié)構(gòu)重構(gòu)是房顫發(fā)生和維持過程中的關(guān)鍵環(huán)節(jié),心房結(jié)構(gòu)重構(gòu)的影響尤為重要。本文探討房顫患者應(yīng)用血管緊張素轉(zhuǎn)換酶抑制劑(鹽酸貝那普利Benazepri1Hydrochloride,商品名
8、:洛汀新)抑制腎素-血管緊張素-醛固酮系統(tǒng),對房顫患者復(fù)律、維持竇律及對心功能的保護(hù)作用。1.資料及方法1.1對象研究對象選擇自2008