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1、生理學(xué)報ActaPhysiologicaSinica,October25,2004,56(5):597-602597http://www.actaps.com.cn研究論文帕金森病大鼠中縫背核5-羥色胺能神經(jīng)元放電頻率和放電形式的變化褚玉霞1,劉健1,2,*,馮潔1,王勇3,張巧俊3,李強11西安交通大學(xué)醫(yī)學(xué)院生理學(xué)教研室;2環(huán)境與疾病相關(guān)基因教育部重點實驗室,西安710061;3西安交通大學(xué)第二醫(yī)院神經(jīng)內(nèi)科,西安710004摘要:實驗采用玻璃微電極細(xì)胞外記錄法,觀察了帕金森病(Parkinson’sdisease,PD)大鼠中
2、縫背核(dorsalraphenucleus,DRN)5-羥色胺(5-hydroxytrypamine,5-HT)能神經(jīng)元電活動的變化。結(jié)果發(fā)現(xiàn),對照組和PD組大鼠DRN中5-HT能神經(jīng)元的放電頻率分別為(1.61±0.56)Hz和(2.61±1.97)Hz,PD組大鼠的放電頻率顯著高于對照組(P<0.05)。在對照組大鼠,79%的神經(jīng)元呈現(xiàn)規(guī)則放電,21%為爆發(fā)式放電；在PD組大鼠，具有規(guī)則、不規(guī)則和爆發(fā)式放電的神經(jīng)元比例分別為36%、16%和47%,爆發(fā)式放電的5-HT能神經(jīng)元比例明顯高于對照組(P<0.05)。結(jié)果表明，帕
3、金森病大鼠DRN中5-HT能神經(jīng)元的放電頻率增高,且爆發(fā)式放電增多。關(guān)鍵詞:帕金森病;中縫背核;5-羥色胺;6-羥多巴胺;電生理學(xué);大鼠中圖分類號:Q462;R338.2+2Changesofdischargerateandpatternof5-hydroxytrypamineneuronsofdorsalraphenucleusinaratmodelofParkinson’sdiseaseCHUYu-Xia1,LIUJian1,2,*,FENGJie1,WANGYong3,ZHANGQiao-Jun3,LiQiang11Dep
4、artmentofPhysiology,SchoolofMedicine,Xi’anJiaoTongUniversity;2KeyLaboratoryofEnviormentandGenesRelatedtoDiseases,Xi’an710061,China;3DepartmentofNeurology,theSecondHospital,Xi’anJiaoTongUniversity,Xi’an710004,ChinaAbstract:Inthepresentstudy,changesoftheneuronalactivit
5、yof5-hydroxytrypamine(5-HT)neuronsofdorsalraphenucleus(DRN)inaratmodelofParkinson’sdisease(PD)wereinvestigatedwithglassmicroelectroderecording.Theresultsshowedthatthedischargeratesof5-HTneuronsincontrolandPDratswere(1.61±0.56)Hzand(2.61±1.97)Hz,respectively.Thedischa
6、rgerateofPDratswassignificantlyincreasedwhencomparedtothatofthecontrolrats.Incontrolrats,79%of5-HTneuronsdischargedregularlyand21%inbursts.InPDrats,however,36%of5-HTneuronsdischargedregularly,16%irregularlyand47%inbursts.Thepercentageof5-HTneuronsdischarginginburstsw
7、asobviouslyhigherthanthatofthecontrolrats(P<0.05).Thedatasuggestthatthedischargerateandburstingpatternof5-HTneuronsinDRNareincreasedinaratmodelofParkinson’sdisease.Keywords:Parkinson’sdisease;dorsalraphenucleus;5-hydroxytrypamine;6-hydroxydopamine;electrophysiology;r
8、at帕金森病(Parkinson’sdisease,PD)是由于黑質(zhì)致能改變。在PD動物和PD患者均發(fā)現(xiàn)基底神經(jīng)節(jié)環(huán)密部多巴胺能神經(jīng)元進(jìn)行性的變性而產(chǎn)生的神經(jīng)退變路的間接通路中底丘腦核(subthalamicnucleus,STN)[1,2]性疾病。多巴胺能神經(jīng)
