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1、·392·全科醫(yī)學(xué)臨床與教育2014年7月第l2卷第4期ClinicalEducationofGeneralPractice]u1.2014.Vo1.12.No.4·臨床研究·不同麻醉深度對(duì)腹腔鏡膽囊切除術(shù)老年患者認(rèn)知功能及應(yīng)激反應(yīng)的影響王毅源陳元良胡崇輝[摘要]目的探討不同麻醉深度對(duì)腹腔鏡膽囊切除術(shù)老年患者認(rèn)知功能及應(yīng)激反應(yīng)的影響。方法70例老年腹腔鏡膽囊切除術(shù)患者隨機(jī)分為兩組,每組35例。腦電雙頻指數(shù)(BIS)監(jiān)測(cè)麻醉深度,A組維持術(shù)中BIS在5O59.B組40~49。采用簡(jiǎn)易精神狀態(tài)量表(MMSE)評(píng)估患者術(shù)前24h、拔管后1h、3
2、h和24h的認(rèn)識(shí)功能,并于麻醉前、切皮前、膽囊切除時(shí)、拔管后30min檢l殞l3患者血清皮質(zhì)醇(Cor)、血糖(Glu)濃度和C一反應(yīng)蛋白(CRP)水平。結(jié)果兩組患者各時(shí)間點(diǎn)MMSE評(píng)分比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(t分別=0.41、0.15、0.43,P均>0.05);麻醉前兩組患者Cor、Glu和CRP水平比較,差異均無(wú)統(tǒng)計(jì)學(xué)意義(f分別=O.37、0.24、0.04,P均>0.05),但B組患者麻醉后各時(shí)間.~.Cor、Glu和CRP水平均低于A組麻醉后,差異均有統(tǒng)計(jì)學(xué)意義(分別=3.87、4.54、3.61、2.47、3.17、3.3
3、6、3.65、5.65、6.63,P均<0.05)。結(jié)論維持術(shù)中BIS在50~59和4O一49對(duì)腹腔鏡膽囊切除術(shù)老年患者認(rèn)知功能的影響相當(dāng).但后者對(duì)應(yīng)激反應(yīng)抑制效果更好。[關(guān)鍵詞1麻醉;腹腔鏡膽囊切除術(shù);腦電雙頻指數(shù);認(rèn)知功能;應(yīng)激反應(yīng)Efectofdiferentdepthofanesthesiaoncognitionfunctionandstressreactioninelderswithlaparoscopicchole.cystectomyWANGYiyuan,CHENYuanliang,HUChonghui.Department
4、ofAnesthesiology,CentralHospitalofJin—hua,Jinhua321000,China[Abstract]ObjectiveToexploretheeffectofdiferentdepthofanesthesiaoncognitionfunctionandstressreactioninelderswithlaparoscopiccholecystectomy.MethodsAtotalof70casesofelderlywithlaparoscopiccholecystectomywererandom
5、lydividedintotwogroupswith35caseseach.Thedepthofanesthesiawasdetectedbybispectralindex(BIS),andtheBISvaluesweremaintaining50to59ingroupAand40to49ingroupBrespectively.Cognitivefunctionsat24hoursbeforeoperarion,3hoursand24hoursafterextubationwereevaluatedbytheminimummentals
6、tateexamination(MMSE)scale.Theserumlevelsofcortisol(Cor),glucose(Glu)andC—reactionprotein(CRP)weredetectedatthetimesofbegin—ningofanesthesia,skinincision,gallbladderremovalingand30minutesafterextubation.ResultsTheMMSEscoresshowednostatisticaldifferencebetweenthetwogroupsa
7、teverypoint(t=O.41,O.15,0.43,P>0.05).ThelevelofCor,GluandCRPatbeginningofanesthesiabetweentwogroupswerenotsignificantlydiferent(t=O.37,0.24,0.04,P>0.05),butthoseingroupBwerelowerthangroupAattimesofskinincision,gallbladderremovalingand30minutesafterextubation(t=3.87,4.54,3
8、.61,2.47,3.17,3.36,3.65,5.65,6.63,P<0.05).ConclusionTheeffectofmaintainingBISat50to59and40to49we