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1、經(jīng)痘堂雜志2014年第27卷第4期·271··論著·發(fā)作性偏頭痛慢性轉(zhuǎn)化的影響因素徐暢,祝東林,林興建,孫琦,石靜萍【摘要】目的探討發(fā)作性偏頭痛慢性轉(zhuǎn)化的影響因素。方法收集126例發(fā)作性偏頭痛(EM)和50例慢性偏頭痛(CM)患者的臨床資料,并進(jìn)行比較。采用Logistic多元回歸方法分析偏頭痛慢性轉(zhuǎn)化的獨(dú)立危險(xiǎn)因素。結(jié)果EM組超重、女性比率,年齡及體重指數(shù)(BMI)顯著低于CM組(均P<0.01),受教育年限顯著高于CM組(P<0.05)。兩組間起病年齡、初發(fā)持續(xù)時(shí)間、初發(fā)疼痛程度及有先兆的比率差異無統(tǒng)計(jì)學(xué)意義(均P>0.05)。EM組初發(fā)頻率、病程、急性期止痛藥物過度使用比率以及焦慮自
2、評(píng)量表(SAS)、抑郁自評(píng)量表(SDS)、匹茲堡睡眠質(zhì)量指數(shù)評(píng)分均顯著低于CM組(P<0.05—0.01)。BMI(OR=1.159,95%C/:1,004—1.338)、SAS(OR=3.100,95%C/:1.360~7.069)、SDS(OR=3.390,95%C/:1.117—10.287)及急性期止痛藥物過度使用(D尺=2.714,95%C/:1.022—7.204)是EM慢性轉(zhuǎn)化的獨(dú)立危險(xiǎn)因素(均P<0.05)。結(jié)論伴有抑郁/焦慮、止痛藥物過度使用和超重是EM慢性轉(zhuǎn)化的獨(dú)立危險(xiǎn)因素?!娟P(guān)鍵詞】偏頭痛;影響因素;焦慮;抑郁【中圖分類號(hào)】R747.2【文獻(xiàn)標(biāo)識(shí)碼】A【文章編號(hào)】10
3、04—1648(2014)04-0271-04InfluencingfactorsinchronicityofepisodicmigraineXUChang,ZHUDong—lin,LIN-jian,eta1.DepartmentofNeurology,BrainHospitalAfiliatedtoNanjingMedicalUnivemity,Nanjing210019,ChinaAbstract:0bjectiveToinvestigateinfluencingfactorsinchronicityofepisodicmigraine.MethodsTheclinicaldataof
4、126episodicmigraine(EM)patientsand50chronicmigraine(CM)patientswereevaluated,andtheresultswerecompared.Muhivariablelogisticregressionanalyseswereusedtopredictedindependentriskfactorsinchronieityofepisodicmigraine.ResultsTheratesofoverweight,femaleandage,bodymassindex(BMI)inEMgroupweresignificantly
5、lowerthanthoseinCMgroup(allP<0.O1).TheeducationyearsinEMgroupwassignificantlyhigherthanthatinCMgroup(P<0.05).Therewasnosignificantdifferenceintheageonset,durationofintialonset,paindegreesofinitialonsetandtheproportionofaura(allP>0.05).Theincipientfrequencyofheadache,courseofdisease,therateofanalge
6、sicsoveruseinacutestage,thescoreofself-ratinganxietyscale(SAS),self-ratingdepressionscale(SDS)andPittsburghsleepqualityindexinEMgroupweresignificantlylowerthanthoseinCMgroup(P<0.05—0.O1).BMI(OR=1.159,95%CI:1.004—1.338),SAS(OR=3.100,95%C/:1.360—7.069),SDS(OR=3.390,95%C/:1.117一10.287)andanalgesicsov
7、eruse(OR=2.714,95%CI:1.022—7.204)weretheindependentriskfactorsinthechronicityofEM(allP<0.05).ConelusioilDepressionoranxiety,analgesicsoveruseandoverweightareindependentriskfactorsinthechronicityofEM.Keywords:migr