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《microRNA調(diào)控上皮-間質(zhì)轉(zhuǎn)化影響卵巢癌侵襲轉(zhuǎn)移的研究進(jìn)展-論文.pdf》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫(kù)。
1、·390·國(guó)際婦產(chǎn)科學(xué)雜志2014年8月第4l卷第4期JIntObstetGynecol，August2014，Vo1．41，No．4·綜述·microRNA調(diào)控上皮一間質(zhì)轉(zhuǎn)化影響卵巢癌侵襲轉(zhuǎn)移的研究進(jìn)展張?jiān)?，張殊【摘要】卵巢癌是女性生殖系統(tǒng)三大惡性腫瘤之一，死亡率居?jì)D科腫瘤之首，卵巢癌的轉(zhuǎn)移是造成患者死亡的重要原因。上皮一間質(zhì)轉(zhuǎn)化(epithelial—mesenchymaltransition，EMT)是上皮細(xì)胞表型向間質(zhì)細(xì)胞表型轉(zhuǎn)變的過(guò)程，與腫瘤侵襲、轉(zhuǎn)移及耐藥等惡性行為密切相關(guān)。MicroRNA(miRNA)是一類內(nèi)源性非編碼的小分子RNA，能在轉(zhuǎn)錄后水平調(diào)控編碼基因表達(dá)，其能調(diào)控EM
2、T的過(guò)程受到越來(lái)越多關(guān)注。多種miRNA在卵巢癌中表達(dá)存在差異，并參與卵巢癌的發(fā)生、發(fā)展過(guò)程，提示miRNA可能用于卵巢癌早期診斷、治療、預(yù)后評(píng)估?，F(xiàn)就近年對(duì)卵巢癌中miRNA調(diào)控EMT機(jī)制及其與卵巢癌侵襲轉(zhuǎn)移關(guān)系的研究進(jìn)行綜述?！娟P(guān)鍵詞】卵巢腫瘤；癌；上皮一問(wèn)質(zhì)轉(zhuǎn)化；微RNAs；腫瘤干細(xì)胞；腫瘤轉(zhuǎn)移RelationshipbetweenmiRNARegulatingEpithelial-MesenchymaiTransitionandMetastasisinOvarianCancerZHANGYue，ZHANGShu．DepartmentofObstetricsandGynecology，尺
3、eHospital，SchoolofMedwine，nnTongUniversity；ShanghaikeyLaboratoryofGynecologicOncology，Sha~ghoi200127，ChinaCorrespondingauthor：ZHANGShu，E-mail：drzhcmgshu@hotmail．COrn【Abstract】Ovariancancerisacommongynecologicalmalignancyandoneofleadingcausesofcancer—relatedmorbidityandmortalityinfemalepatientsaround
4、theglobe．Themetastasisofovariancancerisanimportantfactorincausingdeaths．EMT(epithelial—mesenchymaltransition)referstothetransitionprocessfromthephenotypeofepithelialcellstomesenchymalphenotypeandiscloselyassociatedwiththemalignantprogressionoftumorsinitsinvasionandmetastasis．MicroRNA(miRNA)areaclass
5、ofsmallmoleculeandnoncodingRNAswhichinhibittranslationofthemRNAtranscriptofthegenesexpression，andbecomemoreandmoreconcernedinregulatingEMTprogress．ManykindsofmiRNAexpressedabnormallyandrelatedtotheoccurrenceanddevelopmentofovariancancer，areexpectedtobeusedinearlydiagnosis，treatmentandprognosis．Inthi
6、sreview，wepresentedrecentresearchregardingtheroleofEMTandrelatedmicroRNAsinthemalignantprogressionofovariancancer．【Keywords】Ovarianneoplasms；Carcinoma；Epithelial-mesenchymaltransition；MicroRNAs；Neoplasticstemcells；Neoplasmmetastasis(J，mObstetGynecol，2014，41：390—394，418)卵巢惡性腫瘤是常見(jiàn)的女性生殖系統(tǒng)三大惡性轉(zhuǎn)移的關(guān)鍵所在Ⅲ。微
7、小RNA(microRNA，miRNA)是腫瘤之一，且死亡率最高，5年生存率僅為20％～近年研究發(fā)現(xiàn)的一類調(diào)節(jié)RNA。在卵巢癌中，已經(jīng)30％。卵巢癌極易發(fā)生侵襲和轉(zhuǎn)移，主要通過(guò)直接蔓發(fā)現(xiàn)多種miRNA的改變，越來(lái)越多文獻(xiàn)顯示miRNA延及腹腔種植，直接侵犯鄰近器官并且廣泛種植于能夠調(diào)節(jié)EMT過(guò)程并改變腫瘤特性，將為卵巢癌盆腔腹膜及各個(gè)臟器表面。癌細(xì)胞在與瘤母體分離的診斷及治療提供新的途徑。并向周圍
