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1、第25卷第12期化學(xué)進(jìn)展Vo1.25No.122013年12月PR0GRESSINCHEMISTRYDec.,2013復(fù)雜形貌磁性復(fù)合微球制備及其生物應(yīng)用:}:李恬,王神龍一郭方方時(shí)東陸(1.同濟(jì)大學(xué)材料科學(xué)與5-_程學(xué)院上海200092;2.同濟(jì)大學(xué)醫(yī)學(xué)院生物醫(yī)學(xué)X-程與納米科學(xué)研究院上海200092)摘要具有復(fù)雜形貌的磁性復(fù)合材料顯示出獨(dú)特的物理和化學(xué)性質(zhì),在藥物載體、體外生物檢測、體內(nèi)成像和磁轉(zhuǎn)染、磁熱療等生物醫(yī)學(xué)領(lǐng)域具有良好的應(yīng)用前景。本文就幾種典型的除簡單核-殼結(jié)構(gòu)外的磁性復(fù)合材料的形貌和結(jié)構(gòu)分類、制備方法和
2、應(yīng)用研究進(jìn)展進(jìn)行了全面的綜述,主要包括Janus、Yolk—Shell和介孔結(jié)構(gòu)復(fù)合微球的相關(guān)研究,并對(duì)復(fù)雜形貌的磁性復(fù)合微球制備技術(shù)的改進(jìn)及應(yīng)用上的拓展作出展望。關(guān)鍵詞復(fù)雜形貌非對(duì)稱結(jié)構(gòu)磁性復(fù)合微球生物應(yīng)用中圖分類號(hào):0614.81;TB33文獻(xiàn)標(biāo)識(shí)碼:A文章編號(hào):1005—281X(2013)12—2053—15SynthesisandBiomedicalApplicationsofMagneticNanocompositeswithComplexMorphologiesLiTianWangYilongGuoFan
3、g)rangShiDonglu。(1.SchoolofMaterialsScienceandTechnology,TongjiUniversity,Shanghai200092,China;2.InstituteforBiomedicalEngineeringandNanoScience,Ton~iUniversitySchoolofMedicine,Shanghai200092,China)AbstractMagneticnanocompositeswithcomplexstructuresandsurfacefun
4、ctionalitiesshowtheuniquephysicalandchemicalproperties.Theirapplicationsinthedrugcarrier,bio—detection,invivoimagingandcatalystsareverypromising.Inthisreview,severaltypicalmagneticcompositeswithcomplexarchitectures,includingJanusstructure,Yolk-Shellshapeandmesop
5、orousstructurecompositearethoroughlydiscussed,theprogressesinpreparationmethodandbiomedicalapplicationsarereviewed.Theoutlookofimprovementoffabricationtechnologyandpotentialapplicationsarealsoconcerned.Keywordscomplexmorphology;asymmetricstructures;magneticnanoc
6、omposites;biomedicalapplication4.2JanusmesoporouscompositesContents4.3Yolk—Shellmesoporouscomposites1Introduction4.4Othermesoporouscomposites2ThestudyofJanusmagneticcomposites5Theapplicationofmagneticcomposites2.1Inorganic—inorganicmagneticJanusparticles5.1Theap
7、plicationofJanusmagneticcomposites2.2Inorganic-organicmagneticJanusparticles5.2TheapplicationofYolk—Shellmagneticcomposites3ThestudyofYolk—Shellmagneticcomposites5.3Theapplicationofmagneticmesoporouscompo—4Thestudyofmagneticmesoporouscompositessites4.1Core—Shell
8、mesoporouscomposites6Con11lsjons收稿:2013年5月,收修改稿:2013年8月國家自然科學(xué)基金項(xiàng)目(No.51173135)、上海市科委納米專項(xiàng)(No.11nm0506100)和中央高校基本科研業(yè)務(wù)費(fèi)專項(xiàng)資金資助Correspondingauthore—mail:yilongwang@tongji.