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1、實(shí)用藥物與臨床2013年第16卷第11期PracticalPharmacyAndClinicalRemedies,2013,Vo1.16,No.11·1007·右美托咪定預(yù)防經(jīng)皮腎鏡取石術(shù)患者腰硬聯(lián)合阻滯麻醉后寒戰(zhàn)的臨床觀察吳健,李澎[摘要]目的觀察右美托咪定對(duì)經(jīng)皮腎鏡取石術(shù)患者椎管內(nèi)麻醉后寒戰(zhàn)的預(yù)防作用。方法選擇椎管內(nèi)麻醉下行經(jīng)皮腎鏡取石的患者44例,隨機(jī)平均分為右美托咪定組(D組)和對(duì)照組(C組)。麻醉平面穩(wěn)定后,D組予右美托咪定:負(fù)荷劑量0.4g/kg,15rain泵完,以0.4g/(kg·h)維持;C組泵注生理鹽水,泵注速度及方法同D組。記錄患者麻醉前(TO)、
2、用藥后5min(T1)、手術(shù)60min(T2)、手術(shù)120min(T3)、術(shù)畢(T4)及術(shù)后入麻醉后恢復(fù)室(PACU)即刻(T5)、30min(T6)、60min(T7)的MAP、SpO2、HR、體溫(T)及Ramsay評(píng)分;記錄寒戰(zhàn)分級(jí)及出現(xiàn)時(shí)間;記錄硬膜外腔給藥的間隔時(shí)間。記錄術(shù)中惡心嘔吐、呼吸抑制及患者對(duì)手術(shù)的回憶率等情況。結(jié)果T1~T7時(shí),D組Ramsay評(píng)分明顯高于rID時(shí),且D組Ramsay評(píng)分明顯高于c組(P<0.05);T1~T5時(shí),兩組患者M(jìn)AP、HR低于TO時(shí),D組患者HR低于c組(P<0.05)。D組患者寒戰(zhàn)發(fā)生率明顯低于c組(P<0.01)。D組
3、硬膜外腔給藥的間隔時(shí)間較c組長(zhǎng),差異有統(tǒng)計(jì)學(xué)意義[(130.44-11.1)minvs.(103.44-8.3)min,P<0.05];與TO比較,T3~T5組患者體溫均降低(P<0.05)。D組患者對(duì)手術(shù)的回憶率低于c組(P<0.05)。各時(shí)間點(diǎn)兩組患者的SpO,比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05)。各時(shí)間點(diǎn)兩組患者的體表溫度、寒戰(zhàn)出現(xiàn)的時(shí)間及術(shù)中惡心嘔吐等不良反應(yīng)比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P>0.05)。結(jié)論術(shù)中泵注右美托咪定可安全有效地預(yù)防經(jīng)皮腎鏡取石術(shù)患者椎管內(nèi)麻醉后寒戰(zhàn)的發(fā)生。[關(guān)鍵詞]右美托咪定;經(jīng)皮腎鏡取石;寒戰(zhàn);聯(lián)合阻滯麻醉Clinicalobservati
4、onofpreventiveefectofdexmedetomidineonshiveringaftercorn-binedspinalepiduralanesthesiainpatientsundergoingpercutaneousnephrolithoto-mywUJian”,LIPeng(a.DepartmentofAnesthesiology,b.DepartmentofRespiratoryMedicine,ShengjingHos—pitalofChinaMedicalUniversity,Shenyang110004,China)[Abstract]0b
5、jectiveToobservetheeffectofdexmedetomidineonpreventingshiveringaftercombinedspi—nalepiduralanesthesiainpatientsundergoingpercutaneousnephrolithotomy.MethodsF()rty—fourpatientsscheduledforpercutaneousnephrolithotomyundercombinedspinalepiduralanesthesiawererandomlydividedintotwogroups.Grou
6、pD(n=22)receiveddexmedetomidineasapreloadingdoseof0.4g/kgin15rainfollowedbyamaintaininginfusionof0.4g/(kg.h),whilegroupCreceivednormalsalineinfusionasthecontrolgroup.TheHR,MAP,SpO2,bodytemperature(T)andRamsayscoreswererecordedatthetimepointofpre—anesthesia(TO),5minafteradminis—tration(T1
7、),60mininoperation(T2),120mininoperation(T3),operationfinished(T4),entryofpost—anesthesiaunit(PACU)(T5),30mininPACU(T6)and60mininPACU(T7).Theoccurrencetimeandgradesofshiveringandtheintervaltimeofepiduraladministrationwererecorded.Meanwhile,theadversereactions,suchasnausea