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1、·論著·不同劑量右美托咪定防治腰硬聯(lián)合麻醉后寒戰(zhàn)的臨床研究軻俊峰(通遼市第二人民醫(yī)院麻醉科,內蒙古通遼028000)中圖分類號R969.4;R971.3文獻標志碼A文章編號1672—2124(2014)07—0582—03摘要目的:探討右關托咪定防治腰硬聯(lián)合麻醉后寒戰(zhàn)反應的最小有效劑量。方法:選擇經(jīng)腰硬聯(lián)合麻醉行下腹部及下肢手術的患者136例,隨機分為對照組與3個劑量試驗組,各試驗組麻醉后分別泵注不同劑量的右美托咪定[0.2gg/kg(A組)、0.4pg/kg(B組)、0.6gg/kg(C組)],對照組靜
2、脈泵注生理鹽水。觀察各組患者麻醉前、右美托咪定(或生理鹽水)泵注后15min、30min、60min、術畢各時間點的體溫、寒戰(zhàn)反應發(fā)生率、Ramsay鎮(zhèn)靜評分及藥物不良反應發(fā)生情況。結果:A、B、c組患者泵注右美托咪定后各時間點體溫均低于麻醉前,即均處于低體溫狀態(tài),與對照組比較差異無統(tǒng)計學意義(尸>0.05)。B、C組寒戰(zhàn)程度較輕,寒戰(zhàn)發(fā)生率顯著低于對照組(尸<0.05);A組寒戰(zhàn)程度及寒戰(zhàn)發(fā)生率與對照組比較差異無統(tǒng)計學意義(P>0.05)。泵注右關托咪定后各時間點A組鎮(zhèn)靜Ramsay評分均顯著高于泵注前
3、,其余各組Ramsay評分與泵注前比較差異無統(tǒng)計學意義(P>0.05);B、C組泵注右美托咪定后不同時間點Ramsay評分與對照組比較差異有統(tǒng)計學意義(P<0.05)。C組泵注右美托咪定后有3例出現(xiàn)口干、5例出現(xiàn)心率下降,其余各組均未見明顯不良反應。結論:右關托咪定防治腰硬聯(lián)合麻醉后寒戰(zhàn)的最小有效劑量是0.4gg/kg,既可有效減輕寒戰(zhàn)程度,降低寒戰(zhàn)反應發(fā)生率,又不使患者過度鎮(zhèn)靜,無明顯不良反應。關鍵詞腰硬聯(lián)合麻醉;右美托咪定;低體溫;寒戰(zhàn);最低有效劑量DifferentDosesofDexmedetom
4、idineforPreventionofChillsinPatientsUndergoingCombinedSpinal·-epi-duralAnesthesiaKEJun.feng(Dept.ofAnesthesiology,TongliaoMunicipalSecondPeople’sHospital,InnerMongoliaTongliao028000,China)ABSTRACT0BJECTIVE:Toexploretheminimumeffectivedoseofdexmedetomidine
5、forpreventionofchillsinpatientsunder—goingcombinedspinal—epiduralanesthesia(CSEA).METHODS:Atotalof136patientsundergoingsurgeryoflowerabdomenorlowerlimbfollowingCSEAwererandomlyassignedtoreceivedexmedetomidinel0.2gg/kg(groupA),0.4pg/kg(groupB),0.6pg/kg(gro
6、upC)]orphysiologicalsaline(controlgroup)byvenouspumpinfusion.Patients’bodytemperature,incidenceofchillsreaction,Ramsaysedationscoreandincidenceofadversedrugreactionsbeforeanesthesia,15min,30minand60rainafterpump—inginfusionofdrugsandaftercompletionofsurge
7、rywererecorded.RESULTS:ThebodytemperatureingroupA,BandCatalltimepointsfollowinginfusionofdexmedetomidinewerealllowerthanbeforeanesthesia,indicatinghypothermia;however,nosig—nificantdiferenceswerenotedbetweenthethreetestgroupsandthecontrolgroup(P>O.05).The
8、chillsweremildingroupBandC.andtheincidenceratesofchillsingroupBandgroupCweresignificantlylowerthaninthecontrolgroup(P<0.05);howev—er.nosignificantdiferenceswerenotedbetweengroupAandthecontrolgroup(P>0.05).Ramsayseda