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1、t辱隼^譴化奈毒’@世界華人消化雜志2013年11~28B;21(33):3617—3622wcid@wjgnet.cornISSN1009—3079(print)ISSN2219—2859(online)歹丑4孽孝≯簦謄磐謄貉囂l萋霉§鬟l磐l髫磐爹露l簿磐I磐簦黲藩i零舞l磐≯gi卡馬西平保護(hù)小鼠肝臟缺血再灌注損傷雷延昌,羅盼,李雯雷延昌,羅盼,李雯.南昌大學(xué)附屬感染病醫(yī)院江西省南昌市330006andBeclin.1andLC3IIexpressionafterreperfu一要考粵依賴?yán)籽硬?,主任醫(yī)師.主要從事病毒性肝炎肝衰竭的研究國(guó)家自然科學(xué)基金資助項(xiàng)目,No.81160
2、065sion..CBZtreatmentdecreasedALT/ASTlevels釜箋羹Z?!瘒套髡哓暙I(xiàn)分布:課題設(shè)計(jì)由雷延昌主持:研究過(guò)程由羅盼與李雯significantly2,6and12hafterI/Rcompared胞漿蛋白和細(xì)胞實(shí)施:論文寫作由雷延昌完成withtheI/Rgroupfal1P<0.01).Expressionof器的過(guò)程,對(duì)肝臟通訊作者:雷延昌,主任醫(yī)師,330006,江西省南昌市洪都中大道167號(hào),南昌大學(xué)附屬感染病醫(yī)院ycleihust@sinacomCaspase3in1erseandhept。ceHMGB1籌橐墨電話:0791—88499
3、615cytoplasmictranslocationat6hafterI/Rwere菱現(xiàn),卡西軍促收稿日期:2013—10—30修回日期:2013—11—17接受日期:2013—11—19在線出版日期:2013—11—28alsodecreasedsignificantlyintheCBZgroup進(jìn)肝細(xì)胞自噬治fbothP<0.011.CQanta~onizedtheeffectof療ctl一抗胰蛋白酶BzindecreasingA’LT/ASTlevels,caspase3葛CarbamazepineprotectsexpressionandhepatocyteHMGB1cy
4、toplasmic保護(hù)作用不清楚.trans1ocat{ontheliveragainstischemia/reperfusioninjuryinmiceCONCLUSION:CBZprotectstheliveragainstYan-ChangLei,PanLuo,WenLiI/Rinjuryinmice.⑥2013BaishidengPublishingGroupCo.,Limited.AIYan-ChangLei,PanLuo,WenLi,InfectiousDiseasesrightsreserved.HospitalofNanchangUniversity,Nanchan
5、g330006,Ji。angxiProvince.ChinaSupportedby:NationalNaturalScienceFoundationofKeyWords:Carbamazepine;Ischemia/reperfusion;China.No.8l160065Autophagy,Highmobilitygroupproteincytoplas—C0rresDOndencetO:Yan—ChangLei,ChiefPhysician,mictranslocationInfectiousDiseasesHospita1.NanchangUniversity.167Hong
6、duMiddleRoad,Nanchang330006,JiangxiProvince,China.ycleihust@sina.tomLeiYC,LuoP,LiW.CarbamazepineprotectstheliverReceived:2013—10—30Revised:2013—11—17againstischemia/reperfusioninjuryinmice.ShijieAccepted:2013—·11-19Publishedonline:2013-11-28HuarenXiaohuaZazhi2013;21(33):3617—3622URL:http://www
7、.wjgnet.com/1009—3079/21/3617.a(chǎn)spDOI:http://dx.doi.org/10.11569/wcjd.v21.i33.3617AbstractAIM:Toexploretheefec~ofcarbamazepine(CBZ)onhepaticischemia/reperfusion(I/R)injuryin摘要mice.目的:了解卡馬西平對(duì)肝臟缺血再灌注的保護(hù)作用.METHODS:HepaticischemiainmaleBalb/