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1、理瘤醫(yī)學(xué)2014年5月第22卷第5期MODERNONCOLOGY，May．2014，VOL．22，NO．05．1123．BOJ，2004，23：3270—3281．[11]MillerJK，ShattuckDL，IngallaEQ，eta1．Suppressionofthenega—[10]StutzMA，ShattuckDL，LaedefichMB，eta1．LRIG1negativelytiveregulatorLRIG1contributestoErbB2overexpressioninbreastregulatestheoncogenicEGFrecepto
2、rmutantEGFRvlII[J]．On—cancer[J]．CancerRes，2008，68：8286—8294．cogene，2008，27：5741—5752．(編校：談靜)年齡因素對(duì)肝癌肝切除術(shù)患者長(zhǎng)期預(yù)后的影響苗潤(rùn)晨，許鑫森，陳偉，周延巖，萬(wàn)永，呂毅，劉昌Theefectofageonlong—-termprognosisofpatientswithhepatocellularcarcinoma(HCC)afterresectionsurgeryMiaoRunchen，XuXinsen，ChenWei，ZhouYanyan，WanYong，LvYi，L
3、iuChangDepartmentofHepatobiliarySurgery，TheFirstAffiliatedHospitalofMedicalCollege，Xi"anjiaotongUniversity，ShaanxiXi"an710061，China．【Abstract】Objective：AgeplaysanimportantroleontheprognosisofpatientswithHCCafterresectionsurgery．Whetherolderpatientsshouldreceiveresectionsurgeryremainsco
4、ntroversia1．Weaimtocomparetheclinicopathologi·calfeaturesandprognosesbetweenyoungerandolderpatientswithHCCundergoingresection．Methods：Theclinicalrecordsof172patientswithhepatocellularcarcinomaundergoingresectionsurgerywereanalyzedretrospectively，andthefollow—upofthesepatientswasperform
5、ed．Weinvestigatedthecorrelationbetweenthefactorofageandtheclini—copathologiealfeaturesorprognoses．Results：Theyoungerpatients(≤53)hadbetterliverfunctionalreservebutmoreaggressivetumorfactorsthantheolderpatients(>53)．Afteramedianfollow—up0f31months，87patientsdied．Thecumulative5一yearsurvi
6、valrateswere55．43％inyoungerpatientsand48．31％intheolderpatients(P=0．026)．Usingmultivariateanalysis，wedemonstratedthatagewasanindependentriskfactorassociatedwithoverallsurviva1．Besides，therewere76patientswhohadtumorrecurrenceaftersurgery．Usingmultivariateanalysis，wefailedtofindthattheinc
7、idenceoftumorrecurrenceinyoungerpatientswascomparabletothatintheolderpatients．Conclusion：AgeisariskfactortodeterminethesurvivalofpatientswithHCCwhounderwentresection．However，nocorelationwasobservedbetweenrecurrenceandage．【Keywords】age；hepatocellularcarcinoma；resectionsurgery；prognosi
