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1、中國(guó)當(dāng)代醫(yī)藥2015年6月第22卷第17期·腫瘤醫(yī)學(xué)·老年性tied,細(xì)胞肺癌調(diào)強(qiáng)適形放療同期化療的-臨床研究王人靈方偉達(dá)麥茂梁文勇葉大勝?gòu)V東省開平市中心醫(yī)院腫瘤科，廣東開平529300【摘要】目的探討老年性非小細(xì)胞肺癌調(diào)強(qiáng)適形放療同期化療的臨床效果。方法選取2013年l1月一2014年10月本院收治的80例老年性非小細(xì)胞肺癌患者，將其隨機(jī)分為觀察組和對(duì)照組，各40例。兩組均實(shí)施順鉑聯(lián)合紫杉醇治療方案進(jìn)行化療，對(duì)照組同步實(shí)施常規(guī)放療，觀察組同步實(shí)施調(diào)強(qiáng)適形放療。比較兩組的臨床療效及毒副反應(yīng)。結(jié)果觀察組總有效率為82．50％，高于對(duì)照組的45．00％，差異有
2、統(tǒng)計(jì)學(xué)意義(P<0．05)。兩組患者的藥物毒性反應(yīng)主要有骨髓抑制、放射性食管炎、急性放射性肺炎，兩組的骨髓抑制發(fā)生率差異無(wú)統(tǒng)計(jì)學(xué)意義(0．05)，放射性食管炎、急性放射性肺炎的發(fā)生率差異有統(tǒng)計(jì)學(xué)意義(P<0．05)。結(jié)論在老年性非小細(xì)胞肺癌的治療中，調(diào)強(qiáng)適形放療同期化療與常規(guī)放療比較，具有效果好、毒副反應(yīng)輕等特點(diǎn)。值得臨床推廣應(yīng)用?！娟P(guān)鍵詞】老年性非小細(xì)胞肺癌；調(diào)強(qiáng)適形放療；化療【中圖分類號(hào)】R784．2【文獻(xiàn)標(biāo)識(shí)碼】A【文章編號(hào)】1674—4721(2015)06(b)一0035—03Clinicalstudyonintensitymodulatedco
3、nformalradiationtherapycon·currentchemotherapyintreatmentofelderlynon-smallcelllungcancerWANGRen-lingFANGWei-daMAIMaoLIANGWen-yongYEDa-shengDepartmentofOncology，KaipingCentralHospitalofGuangdongProvince，Kaiping529300，China【Abstract】ObjectiveToinvestigateclinicaleffectofintensitymo
4、dulatedconformalradiationtherapyconcurrentchemotherapyintreatmentofelderlynon-smallcelllungcancer．Methods80elderlypatientswithnon-smallcelllungcanceradmittedintoourhospitalfromNovember2013toOctober2014wereselected，andtheywererandomlydividedintoobservationgroupandthecontrolgroup，th
5、erewere40casesineachgroup．Cisplatinpluspaelitaxelchemotherapyregimenwasimplementedtoallpatients，controlgroupwasimplementedwithconventionalradiotherapy，whileobserva—tiongroupwasimplementedwithintensitymodulatedconformalradiationtherapy．Theclinicaleficacyandtoxicandsidereactionbetwe
6、entwogroupswascomparedrespectively．ResultsThetotaleffectiverateofobservationgroup(82．50％)washigherthanthatofcontrolgroup(45．o0％)，andthedifferencewassignificant(P<0．05)．Drugtoxicandsidereactioninthetwogroupswasmainlybonema~owsuppression，radiationesophagitis，acuteradiationpneumoniti
7、s，theincidencerateofbonemarowsuppressionbetweentwogroupshadnosignificantdifferencefJP>0．05)；theincidencerateofradiationesophagitisandacuteradiationpneumonitishadsignificantdifferenceP<0．05)．ConclusionInthetreatmentofelderlynon-smallcelllungcancer，comparedwithconventionalradiothera
8、py，intensitymodulatedconformalrad
