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1、蚌埠醫(yī)學(xué)院學(xué)報2014年8月第39卷第8期1117[文章編號]1000-2200(2014)08—1117-03·檢驗醫(yī)學(xué)·甲狀腺功能異常對妊娠結(jié)局的影響蔣玉[摘要]目的：探討孕產(chǎn)婦甲狀腺功能異常對妊娠結(jié)局的影響。方法：選擇3778例無甲狀腺疾病史孕產(chǎn)婦，初診時對其甲狀腺功能進行檢查，依據(jù)篩查結(jié)果，分為甲狀腺功能亢進(甲亢)組、甲狀腺功能減退(甲減)組、亞甲減組、其他甲狀腺疾病組和正常對照組。對各組孕產(chǎn)婦的妊娠過程及結(jié)局進行分析。結(jié)果：甲亢組、甲減組、亞甲減組、低甲狀腺素血癥組早產(chǎn)率均顯著高于正常
2、對照組(P<0．O1)；各組不良結(jié)局發(fā)生率均高于正常對照組(P<0．O1)；甲亢組、甲減組、亞甲減組、低甲狀腺素血癥組新生兒5minApgar評分與正常對照組差異均無統(tǒng)計學(xué)意義(P>0．05)，但甲亢組和甲減組新生兒體質(zhì)量均低于正常對照組(P<0．01)；各組甲狀腺功能異常孕產(chǎn)婦胎兒窘迫、胎兒生長受限、妊娠期高血壓疾病及產(chǎn)后感染的發(fā)生率與正常對照組差異均有統(tǒng)計學(xué)意義(P<0．01)，其中甲亢組、甲減組和亞甲減組胎兒窘迫的發(fā)生率均高于正常對照組(P<0．05一P<0．01)，甲亢組和甲減組妊娠期高血
3、壓疾病發(fā)生率均高于正常對照組(P<0．01)。結(jié)論：定期對孕產(chǎn)婦的游離三碘甲狀腺原氨酸、游離甲狀腺素、促甲狀腺激素進行檢測，了解甲狀腺功能，有利于減少產(chǎn)科并發(fā)癥的發(fā)生，對改善妊娠結(jié)局有著重要的意義。[關(guān)鍵詞]甲狀腺疾病；妊娠；并發(fā)癥[中國圖書資料分類法分類號]R581[文獻標(biāo)志碼]ATheefectofabnormalthyroidfunctiononthepregnancyoutcomeJIANGYu(DepartmentofLaboratoryMedwi~，TheMaternalandChil
4、dHealthHospitalofMianyang，MianyangSichuan621000，China)[Abstract]Objective：Toexploretheeffectsofabnormalthyroidfunctiononthepregnancyoutcome．Methods：Threethousandsevenhundredandseventy-eightpregnantwomenwithoutthehistoryofthyroiddiseaseweredividedintot
5、hehyperthyroidismgroup，hypothyreosisgroup，subclinicalhypothyreosisgroup，otherthyroiddiseasegroupandnormalcontrolgroupaccordingtothethyroidfunction．Theprocessesandoutcomesofpregnancybetweenallgroupswereanalyzedandcompared．Results：Thepretermdeliveryrate
6、softhehyperthyroidismgroup，hypothyreosisgroup，subclinicalhypothyreosisgroupandlowthyroidgroupweresignificantlyhigherthanthatofthenormalgroup(P<0．01)．Theincidenceofadverseoutcomeinallgroupswerehigherthanthatinnormalcontrolgroup(P<0．01)．Thedifferencesof
7、theneonatal5minApgarscoresbetweenthehyperthyroidismgroup，hypothyreosisgroup，subclinicalhypothyreosisgroup，lowthyroidgroupandnormalcontrolgroupwerenotstatisticallysignificant(P>0．05)，theneonatalweightsinhyperthyroidismgroupandhypothyreosisgroupwerelowe
8、rthanthatinnormalcontrolgroup(P<0．叭)．Thedifferencesoftheoccurrenceratesofrespiratorydistresssyndrome，intrauterinegrowthretardation，hypertensivedisordercomplicatingpregnancyandpostpartuminfectionbetweenpregnantwithabnormalthyroidfunctionandnorm
