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1、鹽酸帕羅西汀治療腦卒中后抑郁的療效分析作者:毛向瑩單位:長垣縣人民醫(yī)院神經(jīng)內(nèi)科,河南長垣453400【摘要】目的觀察鹽酸帕羅兩汀對腦卒中后抑佃(PSD)的療效。方法60例PSD患者隨機分為治療組和對照紐,每組30例。對照紐給了腦血管病當規(guī)治療,治療紐在常規(guī)治療基礎(chǔ)上給予鹽酸帕羅西汀,每日1次,每次20mg•d-l,晨起口服。2紐療程均為8周。治療前、治療第8周行漢密爾頓抑郁最表(HAMD)評分,并評定其療效和不良反應。結(jié)果治療紐?痊愈10例,顯著進步8例,進步9例,無效3例,有效率90%;對照組顯著進步5例,進步7例,無效18例,有效率40%,2組比較有
2、顯著性差異(χ2=17.526,P<0.05),且治療紐不良反應明顯少于對照紐(χ2=:23.64,P<0.05)o結(jié)論鹽酸帕羅西汀能較好地改善腦卒中后的抑郁情緒,是治療PSD的理想藥物之一?!娟P(guān)鍵詞】帕羅西汀腦卒中抑郁EffectofparoxetinehydrochlorideonpatientswithpoststrokedepressionMAOXiangyingDepartmentofNeurology,thePeople′sHospitalofChangyuanCounty,Changyuan453400,Chi
3、naAbstract:ObjectiveTostudythecurativeeffectsofparoxetinehydrochlorideonthetreatmentofpoststrokedepression(PSD).MethodsSixtypatientswithPSDwererandomlydividedintotreatmentgroup(n=30)andcontrogroup(n=30).Controlgroupwasgivenroutinetreatmentforcerebrovasculardisease,andthetreatmentgroup
4、werereceivedparoxetinehydrochloridetreatment,20mgperdayorallyatdaybreakexceptforcommontreatment.Thecourseoftreatmentwas8weekstorbothgroups.BetoretreatmentandattheSthweekoftreatment,theclinicaleffectsandadversereactionwereassessedwiththeHamiltondepressionscale(HAMD).ResultsIntreatmentg
5、roup,tencasewererecovery,eightcasesweresignificantadvancement,ninecaseswereprogressandinefficiencywastwocases,theeffectivepowerwas90%.Incontrolgroup,fivecasewererecovery,significantadvancementwassevenandinefficiencywaseighteencases,theeffectivepowerwas40%.Therewassignificantdifference
6、betweenthetreatmentgroup(90%)andthecontrogroup(40%)(χ2=17.526,P<0.05).Incidenceoftheadverseeffectswaslowerintreatmentgroupthanthatincontrolgroup(P<0.05).ConclusionParoxetinehydrochloridemaysignificantlyimprovePSDandwillbecomeoneofidealdurgsinthetreatmentofPSD.Keywords:paroxe
7、tine;stroke;depression腦卒中后抑郁(poslstrokedepression,PSD)是腦卒中常見的并發(fā)癥之一,據(jù)國內(nèi)文獻報道,PSD發(fā)生率為20%?75%,表現(xiàn)為情緒低落,自責自罪,興趣減低,對疾病的恢復失去信心,抑郁狀態(tài)能延長疾病的恢復,降低患者的生活質(zhì)量,増加病死率[1]。為此,對PSD患者早期一藥物干預是完全有必耍的,對患者康復也是有益的。作者采用鹽酸帕羅西汀對PSD患者進行治療,取得較好療效。現(xiàn)報道如下。1資料與方法L1一-般資料選擇2005年2月至2007年11月在長垣具人民醫(yī)院神經(jīng)內(nèi)科門診及住院治療的60例PSD患者,隨機將其分
8、為對照組與