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1、納米珍珠粉對大鼠深Ⅱ°燒傷創(chuàng)面愈合的影響作者：崔淑芳，郝光榮，湯球，孫偉，曹平【摘要】目的研究納米珍珠粉對大鼠深Ⅱ°燒傷創(chuàng)面愈合的影響并與微米珍珠粉在燒傷愈合中進(jìn)行藥效比較。方法納米珍珠粉、微米珍珠粉(0.5g/只)分別與甘油按1∶1配制成混合液。以微米珍珠粉組與自然愈合組作對照，納米珍珠粉組為實(shí)驗(yàn)組。測定大鼠14%深Ⅱ°燙傷后7、15、21天的創(chuàng)面愈合率、創(chuàng)面組織學(xué)觀察以及皮膚羥脯氨酸的含量。結(jié)果納米珍珠粉組創(chuàng)面愈合率較微米珍珠粉組、自然愈合組高(P＜0.05或P＜0.01)；燒傷后3天各組皮膚羥脯氨酸含量均低于正常(P＜0.01)，納米珍珠粉組減少程度小于其他組；傷
2、后5天各組HP含量有所恢復(fù)，尤以納米珍珠粉組顯著高于自然愈合組及微米珍珠粉組；10天后各組明顯升高，而納米珍珠粉組HP含量的升高差異有非常顯著性(P＜0.01)。結(jié)論納米珍珠粉可以促進(jìn)大鼠深Ⅱ°燒傷創(chuàng)面的愈合，其愈合作用明顯高于微米珍珠粉(P＜0.05)?！娟P(guān)鍵詞】納米珍珠粉；微米珍珠粉；燒傷；羥脯氨酸【Abstract】ObjectiveTostudytheefficiencyparisonbeticropearlpoentofdeepⅡ°skinscaldsinrats.MethodsNanoandmicropearlpoixedicropearlpoalheali
3、nggroupasthecontrol，nanopearlpoentalgroups.>P＜0.05orP＜0.01).Atthe3thdaypost-injury，thecontentofHPineverygroupalgroup(P＜0.01)，eextent，otetheorehigherthanthatofmicronpearlpoicropearlpoentofdeepⅡ°skinscaldsinratsandparethefunctionicronpearlpoethods1.1PearlpoaceuticalCo.，Ltd)，nanoandmicropea
4、rlpoixedalhydroxyprolinedetectionkit(NanjingJianchengbiotechnologyInstitute，ApprovedNumber20040631).1.2ExperimentalanimalsFemaleSDrats(n＝190，bodyentalAnimalCenter，SecondMilitaryMedicalUniversity).Theratsetaboliccagesfor1entalanimal［SCXK(Hu)2002-0006］；qualifiedcertificateforanimalfacility
5、［No.SCXK(Hu)2002-0026］.1.3EstablishmentofdeepⅡ°skinscaldsmodelinratsThemodeladebasedonthetraditionalmethodsetupbyYangTaimEI［1］.Theratsodelinratsicropearlpoalhealinggroup.Innanopearlpoicropearlpoixtureofnano，micropearlpoalhealinggroupentlasted21days.1.5Observations1.5.1stanceTheenthealing
6、percentageandhealingcircumstancee.1.5.2Dermalhydroxyproline(HP)measurementTissueinthethe3groupsofratsonday3，5，10，15and21afterscaldingalratsskinasacontrol.ThedorsalskintheconnectivetissuefollogofeasuredbydermalHPreagentkit.HPcontentg.1.6DatastatisticsandanalysisInputtingthedataintothepute
7、r，toanalyzethedatailarityofgroupdataeandtheenthealingrateTheskinicropearlpoeofnanopearlpoilaritymorethanthatofmicropearlpoenthealingrateismorequickly.(P<0.01，Seetable1fordetails).Tab.1parisonofeanddevelopmenthealingrateofthedifferenttimes(x±s，%)0Note：paredicropearlpo.2
