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1、AdissertationSubmittedtoNanjingAgriculturalUniversityInpartialfulfillmentoftherequirementsforTheDegreeofDoctoroftheAgronomy(Hydrobiology)CompletedinJune2009指導(dǎo)下,獨(dú)立進(jìn)行研究工作包含任何其他個(gè)人或集體己的個(gè)人和集體,.均己在文中人承擔(dān)。砷’年l瑪t3日學(xué)位論文版權(quán)使用授權(quán)書本學(xué)位論文作者完全了解學(xué)校有關(guān)保留、使用學(xué)位論文的規(guī)定,同意學(xué)校保留并向國(guó)家有關(guān)部門或機(jī)構(gòu)送交論文的復(fù)印件和電子版,允許論文被查閱和
2、借閱。本人授權(quán)南京農(nóng)業(yè)大學(xué)可以將本學(xué)位論文的全部或部分內(nèi)容編入有關(guān)數(shù)據(jù)庫(kù)進(jìn)行檢索,可以采用影印、縮印或掃描等復(fù)制手段保存和匯編學(xué)位論文。保密口,在——年解密后適用本授權(quán)書。本學(xué)位論文屬于不保密口。(請(qǐng)?jiān)谝陨戏娇騼?nèi)打“√")學(xué)位論文作者(需親筆)導(dǎo)師(需親筆)簽名:卅年6疑t歲日叼年易其6龜3.2外膜蛋白(OMP)··············································83.3運(yùn)動(dòng)性(Motility)··············································93.4III型分泌系統(tǒng)(Typ
3、eIIIsecretionsystem,TTSS)·····················93.5毒力基因(VirulenceGenes)····································-114病理和診斷········································-··············114.1概述··············-·········································1l4.2組織病理學(xué)·······································
4、·-·········124.3血液病理學(xué)和血清學(xué)··········································124.4免疫相關(guān)基因的表達(dá)···················-······················124.5分子診斷法··················································125防治·····························································136總結(jié)與展望·························
5、······························15第二章細(xì)菌菌蛻研究進(jìn)展···············································171菌蛻形成的機(jī)制·······-········-··································172菌蛻的制備·······················································183菌蛻的應(yīng)用··················-····································193.1
6、菌蛻疫苗····················································193.2菌蛻疫苗與細(xì)胞免疫·········································"213.3菌蛻疫苗與粘膜免疫·········································-224菌蛻作為抗原、核酸和藥物的載體····································22{ⅡX1255嘔~Ⅵ啦¨一●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●遲緩愛(ài)德華菌菌蛻疫苗的構(gòu)建及
7、動(dòng)物免疫試驗(yàn)4.1茵蛻作為抗原載體···········································"234.2菌蛻作為核酸載體············································284-3菌蛻作為藥物載體···························-················295免疫佐劑········································-····-···········306展望·-····································
8、·······················31第