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1、AdissertationSubmittedtoNanjingAgriculturalUniversityInpartialfulfillmentoftherequirementsforTheDegreeofDoctoroftheAgronomy(Hydrobiology)CompletedinJune2009指導(dǎo)下，獨立進行研究工作包含任何其他個人或集體己的個人和集體，．均己在文中人承擔。砷’年l瑪t3日學位論文版權(quán)使用授權(quán)書本學位論文作者完全了解學校有關(guān)保留、使用學位論文的規(guī)定，同意學校保留并向國家有關(guān)部門或機構(gòu)送交論文的復(fù)印件和電子版，允許論文被查閱和
2、借閱。本人授權(quán)南京農(nóng)業(yè)大學可以將本學位論文的全部或部分內(nèi)容編入有關(guān)數(shù)據(jù)庫進行檢索，可以采用影印、縮印或掃描等復(fù)制手段保存和匯編學位論文。保密口，在——年解密后適用本授權(quán)書。本學位論文屬于不保密口。(請在以上方框內(nèi)打“√")學位論文作者(需親筆)導(dǎo)師(需親筆)簽名：卅年6疑t歲日叼年易其6龜3．2外膜蛋白(OMP)··············································83．3運動性(Motility)··············································93．4III型分泌系統(tǒng)(Typ
3、eIIIsecretionsystem，TTSS)·····················93．5毒力基因(VirulenceGenes)····································-114病理和診斷········································-··············114．1概述··············-·········································1l4．2組織病理學·······································
4、·-·········124．3血液病理學和血清學··········································124．4免疫相關(guān)基因的表達···················-······················124．5分子診斷法··················································125防治·····························································136總結(jié)與展望·························
5、······························15第二章細菌菌蛻研究進展···············································171菌蛻形成的機制·······-········-··································172菌蛻的制備·······················································183菌蛻的應(yīng)用··················-····································193．1
6、菌蛻疫苗····················································193．2菌蛻疫苗與細胞免疫·········································"213．3菌蛻疫苗與粘膜免疫·········································-224菌蛻作為抗原、核酸和藥物的載體····································22{ⅡX1255嘔～Ⅵ啦¨一●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●¨●遲緩愛德華菌菌蛻疫苗的構(gòu)建及
7、動物免疫試驗4．1茵蛻作為抗原載體···········································"234．2菌蛻作為核酸載體············································284-3菌蛻作為藥物載體···························-················295免疫佐劑········································-····-···········306展望·-····································
8、·······················31第
