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1、產(chǎn)婦血清HBVDNA含量對(duì)乳汁和新生兒血清HBVDNA濃度的影響作者：彭其才，許成芳，滕奔琦，侯紅瑛【摘要】【目的】探討乙型肝炎病毒攜帶產(chǎn)婦血清HBVDNA含量對(duì)乳汁和新生兒血清中HBVDNA含量的影響，以指導(dǎo)孕期處理和母乳喂養(yǎng)?！痉椒ā窟x擇乙型肝炎病毒攜帶產(chǎn)婦145例，采用熒光定量聚合酶鏈反應(yīng)(FQ-PCR)技術(shù)對(duì)產(chǎn)婦血清、母乳和新生兒血清HBVDNA進(jìn)行檢測(cè)，并將產(chǎn)婦血清HBVDNA濃度分3級(jí)，分析產(chǎn)婦血清不同HBVDNA濃度級(jí)對(duì)乳汁及新生兒血清HBVDNA濃度的影響?！窘Y(jié)果】血清HBVDNA<500copies/mL
2、的產(chǎn)婦74例，乳汁中檢出HBVDNA陽性為零，新生兒血清HBVDNA陽性1例;血清HBVDNA濃度為500～1.0×106copies/mL產(chǎn)婦30例，乳汁中檢出HBVDNA陽性為3例，新生兒血清HBVDNA陽性1例;血清HBVDNA濃度為≥1.0×106copies/mL產(chǎn)婦41例，乳汁中檢出HBVDNA陽性為36例，陽性率為87.8%，新生兒血清HBVDNA陽性僅3例?！窘Y(jié)論】產(chǎn)婦血清中HBVDNA≥1.0×106copies/mL時(shí)，乳汁中HBVDNA陽性率大幅度增加，而當(dāng)產(chǎn)婦血清HBVDNA濃度小于1.0×106copi
3、es/mL，乳汁中HBVDNA檢出率極低。產(chǎn)婦血清HBVDNA濃度對(duì)宮內(nèi)感染影響不大?！娟P(guān)鍵詞】HBVDNA;母嬰傳播;母乳喂養(yǎng);熒光定量聚合酶鏈反應(yīng)11 Abstract：【Objective】ToinvestigatetheeffectofmaternalHBV?鄄DNAconcentrationonthatofthebreastmilkofpostpartumandneonatuswithchronicHBVinfection.Soastoguidethetreatmentduringpregnancyandbreastf
4、eeding.【Methods】HBVDNAlevelsinserum，breastmilk，andneonatusserumweredetectedbyfluorescentquantitativepolymerasechainreactionin145postpartumwomenwithchronicHBVinfection.SerumHBVDNAwasgradedintothreelevels.TheeffectofdifferentgradeofmaternalserumHBVDNAonthebreastmilkand
5、neonatewasanalyzed.【Result】Seventy-fourcasesofmaternalserumHBVDNAquantitywere<500copies/mL，twooftheirbreastmilkHBV-DNAquantitywerepositive，oneneonatalserumHBVDNAquantitywaspositive.ThiritycasesofmaternalserumHBVDNAquantityrangedof500～1.0×106copies/mL，3casesshowedp
6、ositiveinbreastmilk，oneneonatalserumHBV-DNAquantityshowedpositive.Forty-onecasesofmaternalserumHBVDNAquantitywere>1.0×106copies/mL，theHBVDNApositiverateinbreastmilkreachedto87.8%(36cases)，onlythreecasesneonatusshowedpositiveinthereserumHBVDNAquantity.【Conclusions】
7、WhenmaternalserumHBVDNAquantitygoesbeyond>1.0×106copies/mL，11theHBVDNApositiverateinbreastmilkincreasessharply，whenserumHBVDNAquantitygoesbelow1.0×106copies/mL，theHBVDNApositiverateinbreastmilkisverylow.MaternalserumHBVDNAconcentrationhaslittleeffectonintrauterine
8、infection. 我國是乙型肝炎病毒(HBV)感染高發(fā)區(qū)，陳志英等[1]調(diào)查報(bào)道產(chǎn)婦HBV感染度高達(dá)23.51%。如何降低HBV感染率，阻斷HBV的母嬰傳播是研究重點(diǎn)。目前對(duì)于乙肝攜帶者妊娠后應(yīng)用乙肝免疫球蛋白阻斷HBV宮內(nèi)感染的效果[2-4]和產(chǎn)后母乳喂
