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1、中波紫外線照射治療絕經(jīng)后骨質(zhì)疏松的臨床研究作者:武密山趙素芝武中建張潔【摘要】目的探討中波紫外線照射儀對絕經(jīng)后骨質(zhì)疏松的治療作用。方法選擇符合診斷標(biāo)準(zhǔn)的絕經(jīng)后骨質(zhì)疏松患者99例隨機(jī)分為A、B、C三組,在A組35例腎陽虛型絕經(jīng)后骨質(zhì)疏松患者用中波紫外線照射治療;B組34例腎陰虛型絕經(jīng)后骨質(zhì)疏松患者用中波紫外線照射治療,兩組均加服鈣劑(2g/d)。對照組C組,30例絕經(jīng)后骨質(zhì)疏松患者肌注鮭魚降鈣素,同時(shí)加服鈣劑(2g/d)。觀察治療前后血清1,25(OH)2D3、YoungZ、腰椎骨密度(BMD)的變化。結(jié)果中波紫外線照射治療腎陽虛組血清1,25(OH)2D3、Yo
2、ungZ、腰椎BMD在治療前后差異均有顯著性,與腎陰虛組比較有顯著差異。C組各觀察指標(biāo)無明顯變化。結(jié)論中波紫外線照射對絕經(jīng)后腎陽虛型骨質(zhì)疏松有較好的療效,可提高骨密度,改善骨代謝?!娟P(guān)鍵詞】中波紫外線照射儀;腎陽虛;絕經(jīng)后骨質(zhì)疏松;骨密度;1,25(OH)2D3 【Abstract】ObjectiveTostudytheroleofUVBirradiateinstrumentinthepatientswithpostmenopausalosteoporosis.Methods99postmenopausalosteoporosispatients10were
3、randomlydividedintoA,BandCgroups.IngroupA,35patientswithdeficiencyofkidneyyangpostmenopausalosteoporosisweregivenirradiationwithUVBirradiateinstrument.IngroupB,34patientswithdeficiencyofkidneyyinpostmenopausalosteoporosisweregivenirradiationwithUVBirradiateinstrument.Andinthetwog
4、roups,theyweretookelementarycalcium(2g/d).InthecontrolgroupC,30patientswithpostmenopausalosteoporosiswereinjectedsalmoncalcitonin(CT)andweretookelementarycalcium(2g/d).Theserum1,25(OH)2D3andtheYoungZandbonemineraldensity(BMD)changeweredetectedbeforeandafterthetreatment.ResultsTheleve
5、lsofserum1,25(OH)2D3andYoungZandBMDweresignificantlyincreasedinthedeficiencyofkidneyyanggroupafterUVBirradiateinstrumentandtherewasnochangeingroupC.Theeffectiveratewas90%,therewasremarkablydifferenceaftertreatmentthanbeforeinthedeficiencyofkidneyyingroup.ConclusionsUVBirradiatein
6、strumentisaneffectivecureintheimprovementofbonemetabolismofosteoporosis. 【Keywords】UVBirradiateinstrument;Deficiencyofkidneyyang;Postmenopausalosteoporosis;Bonemineraldensity(BMD);1,25(OH)2D310 研究表明,補(bǔ)腎陽中藥可明顯抑制骨吸收、促進(jìn)骨形成、有效地防治骨質(zhì)疏松〔1〕。近年來,國內(nèi)學(xué)者相繼研制出UVB燈,并進(jìn)行了鈣磷代謝〔2〕、輻射損傷〔3〕及抗骨質(zhì)疏松的動(dòng)物實(shí)
7、驗(yàn)研究〔4〕。根據(jù)“天人相應(yīng)”,腎陽來自太陽光照,本文以骨質(zhì)疏松患者為研究對象,觀察接受不同強(qiáng)度的太陽光照射對腎陽虛型及腎陰虛型骨質(zhì)疏松患者1,25(OH)2D3和骨密度等相關(guān)指標(biāo)的影響,探討陽光中紫外線照射對防治骨質(zhì)疏松及對腎陽虛恢復(fù)的作用,并對中波紫外線照射治療骨質(zhì)疏松進(jìn)行臨床研究?! ?資料與方法 1.1研究對象2007年8月至2009年4月在河北醫(yī)科大學(xué)骨質(zhì)疏松??崎T診和石家莊市橋東區(qū)醫(yī)院門診分別選擇田間勞作的農(nóng)民和大城市里寫字樓陰面辦公室工作的白領(lǐng)(接受不同強(qiáng)度的太陽光照射)絕經(jīng)后骨質(zhì)疏松患者共99例。(1)診斷標(biāo)準(zhǔn):西醫(yī)的骨質(zhì)疏松診斷標(biāo)準(zhǔn)參照《中國
8、人原發(fā)性骨質(zhì)疏松診斷標(biāo)準(zhǔn)