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1、中波紫外線照射治療絕經(jīng)后骨質(zhì)疏松臨床探究作者:武密山趙素芝武中建張潔【摘要】目的探討中波紫外線照射儀對(duì)絕經(jīng)后骨質(zhì)疏松的治療作用。方法選擇符合診斷標(biāo)準(zhǔn)的絕經(jīng)后骨質(zhì)疏松患者99例隨機(jī)分為A、B、C三組,在A組35例腎陽(yáng)虛型絕經(jīng)后骨質(zhì)疏松患者用中波紫外線照射治療;B組34例腎陰虛型絕經(jīng)后骨質(zhì)疏松患者用中波紫外線照射治療,兩組均加服鈣劑(2g/d)o對(duì)照組C組,30例絕經(jīng)后骨質(zhì)疏松患者肌注鮭魚(yú)降鈣素,同時(shí)加服鈣劑(2g/d)o觀察治療前后血清l,25(0H)2D3、YoungZ.腰椎骨密度(BMD)的變化。結(jié)
2、果中波紫外線照射治療腎陽(yáng)虛組血清1,25(0H)2D3、YoungZ.腰椎BMD在治療前后差異均有顯著性,與腎陰虛組比較有顯著差異。C組各觀察指標(biāo)無(wú)明顯變化。結(jié)論中波紫外線照射對(duì)絕經(jīng)后腎陽(yáng)虛型骨質(zhì)疏松有較好的療效,可提高骨密度,改善骨代謝。【關(guān)鍵詞】中波紫外線照射儀;腎陽(yáng)虛;絕經(jīng)后骨質(zhì)疏松;骨密度;1,25(OH)2D3[Abstract]ObjectiveTostudytheroleofUVBirradiateinstrumentinthepatientswithpostmenopausaloste
3、oporosis?Methods99postmenopausalosteoporosispatientswererandomlydividedintoA,BandCgroups?IngroupA,35patientswithdeficiencyofkidneyyangpostmenopausalosteoporosisweregivenirradiationwithUVBirradiateinstrument?IngroupB,34patientswithdeficiencyofkidneyyinpo
4、stmenopausalosteoporosisweregivenirradiationwithUVBirradiateinstrument.Andinthetwogroups,theyweretookelementarycalcium(2g/d)?InthecontrolgroupC,30patientswithpostmenopausalosteoporosiswereinjectedsalmoncalcitonin(CT)andweretookelementarycalcium(2g/d).Th
5、eserum1,25(OH)2D3andtheYoungZandbonemineraldensity(BMD)changeweredetectedbeforeandafterthetreatment.ResuItsThelevelsofserum1,25(OH)2D3andYoungZandBMDweresignificantlyincreasedinthedeficiencyofkidneyyanggroupafterUVBirradiateinstrumentandtherewasnochange
6、ingroupC.Theeffectiveratewas90%,therewasremarkablydifferenceaftertreatmentthanbeforeinthedeficiencyofkidneyyingroup.ConclusionsUVBirradiateinstrumentisaneffectivecureintheimprovementofbonemetabolismofosteoporosis.【Keywords】UVBirradiateinstrument;Deficie
7、ncyofkidneyyang;Postmenopausalosteoporosis;Bonemineraldensity(BMD);1,25(OH)2D3研究表明,補(bǔ)腎陽(yáng)中藥可明顯抑制骨吸收、促進(jìn)骨形成、有效地防治骨質(zhì)疏松(l)o近年來(lái),國(guó)內(nèi)學(xué)者相繼研制出UVB燈,并進(jìn)行了鈣磷代謝(2〕、輻射損傷(3〕及抗骨質(zhì)疏松的動(dòng)物實(shí)驗(yàn)研究(4〕。根據(jù)"天人相應(yīng)”,腎陽(yáng)來(lái)自太陽(yáng)光照,本文以骨質(zhì)疏松患者為研究對(duì)象,觀察接受不同強(qiáng)度的太陽(yáng)光照射對(duì)腎陽(yáng)虛型及腎陰虛型骨質(zhì)疏松患者1,25(OH)2D3和骨密度等相關(guān)指標(biāo)
8、的影響,探討陽(yáng)光中紫外線照射對(duì)防治骨質(zhì)疏松及對(duì)腎陽(yáng)虛恢復(fù)的作用,并對(duì)中波紫外線照射治療骨質(zhì)疏松進(jìn)行臨床研究。1資料與方法1.1研究對(duì)象2007年8月至2009年4月在河北醫(yī)科大學(xué)骨質(zhì)疏松專(zhuān)科門(mén)診和石家莊市橋東區(qū)醫(yī)院門(mén)診分別選擇田間勞作的農(nóng)民和大城市里寫(xiě)字樓陰面辦公室工作的白領(lǐng)(接受不同強(qiáng)度的太陽(yáng)光照射)絕經(jīng)后骨質(zhì)疏松患者共99例。(1)診斷標(biāo)準(zhǔn):西醫(yī)的骨質(zhì)疏松診斷標(biāo)準(zhǔn)參照《中國(guó)人原發(fā)性骨質(zhì)疏松診斷標(biāo)準(zhǔn)(試行)》〔5),根據(jù)國(guó)際診斷標(biāo)準(zhǔn),同時(shí)結(jié)合中國(guó)人的特