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《醫(yī)藥學(xué)臨床醫(yī)學(xué)畢業(yè)論文 微創(chuàng)外科在頸廓清術(shù)中應(yīng)用的臨床前評(píng)價(jià)》由會(huì)員上傳分享,免費(fèi)在線閱讀,更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、湖南師范大學(xué)本科畢業(yè)論文考籍號(hào):XXXXXXXXX姓名:XXX專(zhuān)業(yè):醫(yī)藥學(xué)臨床醫(yī)學(xué)論文題目:微創(chuàng)外科在頸廓清術(shù)中應(yīng)用的臨床前評(píng)價(jià)指導(dǎo)老師:XXX二〇一一年十二月十日作者:易慧明況光儀白殿卿許晨耘趙質(zhì)彬魏欣龔選舉符志龍【摘要】目的于動(dòng)物實(shí)驗(yàn)中探討微創(chuàng)外科在頸廓清手術(shù)中應(yīng)用的可行性。方法選取12只免疫后的健康成年土狗,以3%戊巴比妥鈉(30mg/kg)施行靜脈麻醉,其中6只取頸側(cè)中部30mm長(zhǎng)的模型切口,游離頸皮肌皮瓣后,用兩把常規(guī)小拉鉤拉開(kāi)皮瓣,置入0°內(nèi)鏡4mm鼻竇內(nèi)鏡為照明光源,在直視或電視介導(dǎo)下用常規(guī)外科器械實(shí)施改良根治性頸廓清術(shù)加頜下腺、甲狀腺和半邊甲狀軟骨板切除手術(shù);另外
2、6只取頸側(cè)100mm長(zhǎng)斜行切口實(shí)施改良根治性頸廓清術(shù)加頜下腺、甲狀腺和半邊甲狀軟骨板切除手術(shù)。結(jié)果(1)小切口組術(shù)中耗時(shí)(100±20)min,術(shù)中出血量為(50±30)ml,實(shí)驗(yàn)狗術(shù)后(2±0.5)天自由進(jìn)食并自由活動(dòng),術(shù)后(7±1)天傷口愈合拆線,術(shù)后(10±2)天基本恢復(fù)術(shù)前體重。(2)大切口組術(shù)中耗時(shí)(80±20)min,術(shù)中出血量為(30±20)ml,實(shí)驗(yàn)狗術(shù)后(3±0.5)天自由進(jìn)食并自由活動(dòng),術(shù)后(8±1)天傷口愈合拆線,術(shù)后(13±4)天基本恢復(fù)術(shù)前體重。所有實(shí)驗(yàn)狗術(shù)后無(wú)傷口感染、皮下積液、明顯消瘦、死亡等并發(fā)癥出現(xiàn)。結(jié)論在電視內(nèi)鏡介導(dǎo)下用常規(guī)外科器械通過(guò)一個(gè)微小
3、切口即可實(shí)施狗頸廓清術(shù)而達(dá)到微創(chuàng)外科目的,此微創(chuàng)頸廓清技術(shù)值得進(jìn)一步在臨床試用。【關(guān)鍵詞】微創(chuàng)外科頸廓清術(shù)臨床前評(píng)價(jià)Preclinicalevaluationofapplicationofminimallyinvasivesurgeryinradicalneckdissection【Abstract】ObjectiveToevaluatetheapplicationofminimallyinvasivesurgery(MIS)inradicalneckdissectionusingdogasapreclinicalmodel.MethodsTwelveimmunizedhealt
4、hadultmongreldogswerechosen.Anesthesiawasmaintainedwith3%pentobarbitalsodiumbyI.V.Sixofthedogsweretakena30mmhorizontalskinincisioninthemiddleareaoflateralneck.Aftermusculuscutaneouscolli(MCC)weredivided,twosmallconventionalretractorswereinsertedtoretractthestrapmusclesanda0.4mmsinusendoscopew
5、asinsertedaslightsource.Modifiedradicalneckdissectionplusexcisionofsubmandibularsalivary,thyroidlobeandhalf-thyroidcartilagewasperformedwithconventionalinstrumentsondirectvisualorbyvideo-assisted.Theothersixdogsweretakena100mmobliquelateralneckincision,andmodifiedradicalneckdissectionplusexci
6、sionofsubmandibularsalivary,thyroidlobeandhalf-thyroidcartilagewasperformedwithconventionalinstruments.ResultsIngroupofsmallincision,theoperationtimewas(100±20)minutes.Theoperativebleedingvolumewas(50±30)ml.Thesedogsresumednormalfood/waterintakenandactivity(2±0.5)daysaftertheoperation.Woundhe
7、alingwascompleted(7±1)dayslater.Theweightwasrecoveredasbefore(10±2)dayslater.Ingroupofbigincision,theoperationtimewas(80±20)minutes.Theoperativebleedingvolumewas(30±20)ml.Thesedogsresumednormalfood/waterintakenandactivity(3±0.5)daysaftertheop