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1、Glomerulopathies–IgAnephropathyIgAnephropathy-PathogenesisGlomerulopathies–IgAnephropathyIgAnephropathy-PathogenesisMesangialIgA?promotesglomerularinflammation?aseriesofevents?…….?cancauseendstagerenaldiseaseGlomerulopathies–IgAnephropathyGlomerulopathies–IgAnephropathyIgAnephropa
2、thy-PathogenesisWhatspecificmechanismsinfluencethedepositionofIgAanditsinitiationofinflammation?Glomerulopathies–IgAnephropathyGlomerulopathies–IgAnephropathyIgAnephropathy-PathogenesistightlyTcellcontrolledprocessesinhealthmostpolymericIgAisproducedinthemucosalimmunesystemisinvol
3、vedinmucosaldefensethebonemarrowproducesmonomericIgA,whichreachesthecirculationGlomerulopathies–IgAnephropathyGlomerulopathies–IgAnephropathyIgAnephropathy-PathogenesisinIgAnephropathysynthesisofpolymericIgAisincreasedinthebonemarrowanddecreasedinthemucosaGlomerulopathies–IgAnephr
4、opathyGlomerulopathies–IgAnephropathyGlomerulopathies–IgAnephropathyIgAnephropathy-PathogenesisYesitisGlomerulopathies–IgAnephropathyIgAnephropathy-PathogenesisWhymightthishappen?ThisprocessisverytightlyTcellregulatedInresponsetoamucosalantigen,Tcellsreachthecirculation,butwillret
5、urntothemucosatosynthesizepolymericIgAiftheyexpressalpha4beta7,themucosalhomingreceptorIfontheotherhand,asystemicantigenisconfronted,Tcellswillhometothemarrowiftheyexpressthealpha4beta1systemichomingreceptorGlomerulopathies–IgAnephropathyGlomerulopathies–IgAnephropathyGlomerulopat
6、hies–IgAnephropathyIgAnephropathy-PathogenesisinIgAnephropathy-theseprocessesisabnormalthereisanexaggerationofsystemichomingreceptorexpression,whichwoulddriveTcellsnotbacktothemucosabuttowardsthemarrow?theabnormalsiteofIgA1production,whichisoneofthefeaturesofIgAnephropathyGlomerul
7、opathies–IgAnephropathyGlomerulopathies–IgAnephropathyIgAnephropathy-PathogenesisinIgAnephropathy-theseprocessesisabnormalbutnotonlythereisanexaggerationofsystemichomingreceptorexpression,whichwoulddriveTcellsnotbacktothemucosabuttowardsthemarrow?theabnormalsiteofIgA1production,wh
8、ichisoneofthefeaturesofIgAnephrop
