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1、授予單位代碼10089學(xué)號或申請?zhí)?0153252中國圖書分類號R739.41HebeiMedicalUniversity碩士學(xué)位論文專業(yè)學(xué)位神經(jīng)膠質(zhì)瘤靶向治療的研究進(jìn)展研究生：韓新旺導(dǎo)師：扈玉華教授專業(yè)：外科學(xué)二級學(xué)院：河北醫(yī)科大學(xué)第二醫(yī)院2018年3月目錄中文摘要············································································································1英文摘要········································
2、····································································2英文縮寫············································································································3綜述神經(jīng)膠質(zhì)瘤靶向治療的研究進(jìn)展··························································5致謝····························
3、······················································································28個人簡歷··········································································································29中文摘要神經(jīng)膠質(zhì)瘤靶向治療的研究進(jìn)展摘要目的：總結(jié)神經(jīng)膠質(zhì)瘤靶向治療的研究進(jìn)展內(nèi)容：神經(jīng)膠質(zhì)瘤自發(fā)現(xiàn)已有百余年，但是惡性神經(jīng)膠質(zhì)瘤目前仍不能治愈，且中位無進(jìn)展生存期(MPFS
4、)及中位總生存期(MOS)都較短。隨著科研發(fā)展，多條信號通路已被發(fā)現(xiàn)，一些新興靶向抗腫瘤藥物應(yīng)運(yùn)而生，給神經(jīng)膠質(zhì)瘤的醫(yī)治帶來了新希望。本研究通過查閱前人的發(fā)現(xiàn)及最新臨床試驗(yàn)進(jìn)展，總結(jié)神經(jīng)膠質(zhì)瘤的信號通路及相對信號通路的靶向藥物，分析神經(jīng)膠質(zhì)瘤信號通路之間是否存在相關(guān)性，為臨床醫(yī)治膠質(zhì)瘤提供一定的指導(dǎo)作用。結(jié)果：使用萬方數(shù)據(jù)知識服務(wù)平臺、中國知網(wǎng)、Pubmed等網(wǎng)站查閱近5年國內(nèi)外期刊、學(xué)位論文、著作等，總結(jié)分析神經(jīng)膠質(zhì)瘤信號通路的新發(fā)現(xiàn)、新進(jìn)展。結(jié)論：盡管神經(jīng)膠質(zhì)瘤仍然被人們稱為是不可治愈的疾病，但是目前的靶向治療確實(shí)使患者的中位無進(jìn)展生存期及中位總生存期延長了，它也
5、為將成為未來戰(zhàn)勝神經(jīng)膠質(zhì)瘤的一個強(qiáng)有力武器。關(guān)鍵詞：神經(jīng)膠質(zhì)瘤,靶向治療,靶向藥物,通路,進(jìn)展1英文摘要ResearchprogressintargetedtherapyforgliomaABSTRACTObjective:Summarizetheresearchprogressoftargetedtherapyforglioma.Content:Gliomahasbeendiscoveredforover100years,butmalignantgliomacannotbecuredyetatpresent,andthemedianprogressionfreesu
6、rvival(MPFS)andmedianoverallsurvival(MOS)forpatientsareallshort.Withthedevelopmentofscientificresearch,multiplesignalingpathwayshavebeencaughtsightof,atthesametime,someanti-tumordrugshaveemerged,whichbringsnewhopetothetreatmentofglioma.Bylookingupforthepreviousfindingsandthelatestclinic
7、altrials,thestudysummarizesthesignalpathwayaswellastherelativetargetingdrugofglioma,andanalyseswhetherthereisacorrelationbetweengliomasignalingpathwaytoprovidesomeguidanceforclinicaltreatmentofglioma.Results:Bymeansofconsultingtheperiodicals,dissertations,booksandsoonathomeanda
