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1、瑞舒伐他汀對急性冠脈綜合征患者動脈粥樣硬化的療效觀察郭素萍1劉暢1高傳玉2(1鄭州大學(xué)附屬鄭州中心醫(yī)院急診科450007;2河南省人民醫(yī)院心內(nèi)科450052)【中圖分類號】R972+.6【文獻標(biāo)識碼】A【文章編號】1672-5085(2012)50-0164-02【摘要】目的觀察瑞舒伐他汀對急性冠脈綜合征患者頸動脈粥樣硬化斑塊的影響。方法120例急性冠脈綜合征患者合并頸動脈粥樣斑塊,隨機分為阿托伐他汀組60例,瑞舒伐他汀組60例,隨訪6個月,觀察血脂及血漿hs-C反應(yīng)蛋R(hs-CPR)的水平,并測定頸動脈內(nèi)
2、膜屮層厚度(IMT)的改變。結(jié)果瑞舒伐他汀組及阿托伐他汀組患者治療6個月后,總膽固醇(TC>、低密度脂蛋白(LDL-C)及hs-CPR均有明顯不降(P<0.05);高密度脂蛋白(HDL)在阿托伐他汀組無明顯變化,瑞舒伐他汀組明顯升高(P<0.05)o瑞舒伐他汀組患者治療6個月后,頸動脈內(nèi)膜屮層厚度(IMT)明顯K降(P<0.05),而阿托伐他汀組治療6個月后,頸動脈N膜屮層厚度(IMT)無明顯變化。結(jié)論瑞舒伐他汀在急性冠脈綜合征患者屮通過調(diào)脂及降hs-CPR,起到穩(wěn)定逆轉(zhuǎn)斑塊的作用?!娟P(guān)鍵詞
3、】瑞舒伐他汀急性冠脈綜合征動脈粥樣硬化CurativeeffectofrosuvastatinonatheroscleroticplaquesinpatientswithacutecoronarysyndromeGUOSu-ping;LIUChang;GAOChuanyu(1.DepartmentofEmergency,ZhengzhouCentralHospitalAffiliatedtoZhengzhouUniversity.Zhengzhou450007,China.2.Departmentofcard
4、iology,HenanprovincialPeople’sHospital,450007,China.)【Abstract】ObjectiveToexploretheCurativeeffectofrosuvastatinoncarotidatheroscleroticplaquesinpatientswithacutecoronarysyndrome.Methods120patientsofacutecoronarysyndromewithcarotidatheroscleroticplaqu
5、eswereselected.Theyweredividedintorosuvastatingrouporatorvastatingroup(for6months)atrandom.Theserumlevelsoflipids,high-sensitivityC-reactiveprotein(hs-CRP)andcarotidIMTweremeasuredatthebaselineand6monthsafterthetreatmentrespectively.ResultsAttheendof6months
6、,thepatientsinatorvastatingroupandrosuvastatingroupshowedsignificantlyreducedtotalcholesterol,LDL-Candhs-CRP(P<0.05).ThedifferencesofHDLinatorvastatingrouponadmissionwasnotsignificant(P>0.05).SerumHDLlevelwassignificantlyincreasedinrosuvastatingroup(P
7、<0.05).Theintimamediathickness(IMT)ofthecommoncarotidarterywasreducedsignificantlyaftera6-monthrosuvastatintherapy(P<0.05),butalmostremainedunchangedafteratorvastatintherapy.Conclusionrosuvastatintherapycouldsignificantlydecreasetheserumlevelsoflipids
8、andhigh-sensitivityC-reactiveprotein(hs-CRP),soitmightresisttheatherosclerosisandreversetheplaques.【Keywords]Rosuvastatinacutecoronarysyndromeatheroscleroticplaques急性冠脈綜合征(ACS)主要由不穩(wěn)定的冠狀動脈粥樣硬化(AS>斑塊出現(xiàn)裂縫