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《延遲pci對(duì)急性st段抬高型心肌梗死患者血漿n-末端腦鈉素原影響及臨床意義》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在工程資料-天天文庫(kù)。
1、延遲PCI對(duì)急性ST段抬高型心肌梗死患者血漿N-末端腦鈉素原影響及臨床意義陳子國(guó)黃琦磊王光友(福建醫(yī)科大學(xué)附屬南平第一醫(yī)院心內(nèi)科福建南平353000)【屮圖分類號(hào)】R542.2【文獻(xiàn)標(biāo)識(shí)碼】A【文章編號(hào)】1672-5085(2011)43-0011-03【摘要】目的研究急性ST段抬高型心肌梗死患者延遲PCI術(shù)前及術(shù)后血漿N-末端腦鈉素原水平變化，探討延遲PCI對(duì)心功能的影響。方法選擇住院治療的急性ST段抬高型心肌梗死患者80例，根據(jù)是否行延遲PCI術(shù)分為兩組，兩組患者均于心梗后1周、術(shù)前1天、術(shù)后3天、6個(gè)月檢測(cè)血漿腦鈉素N端前體肽水平的
2、變化，分別于心梗后1周、術(shù)前1天、術(shù)后3天、6個(gè)月做心臟超聲檢查,測(cè)定左室射血分?jǐn)?shù)及左室舒張末期容積，對(duì)比PCI組和非PCI組兩組患者心臟超聲和N-末端腦鈉素原的動(dòng)態(tài)變化。結(jié)果PCI組術(shù)后3天腦鈉素N端前體肽水平明顯下降(P<0.01)；6個(gè)月后PCI組的N-末端腦鈉素原明顯低于非PCI組(P<0.01),PCI組的左室射血分?jǐn)?shù)值高于非PCI組(P<0.05),非PCI組左室舒張末期容積明顯大于PCI組(P<0.05)。結(jié)論延遲PCI能改善急性心肌梗死患者的心功能?！娟P(guān)鍵詞】延遲經(jīng)皮冠狀動(dòng)脈介入N-末端腦鈉素原心功能Theeffectof
3、delayedPCIonNT-proBNPandclinicalsignificanceinpatientswithacuteST-segmentelevationmyocardialinfarction【Abstract】ObjectiveTostudychangesofplasmalevelofN-terminalproBNP(NT-proBNP)beforeandafterdelayedpercutaneouscoronaryintervention(PCI)inthepatientswithacuteST-segmenteleva
4、tionmyocardialinfarction(STEMI),investigatetheeffectofdelayedPCIoncardiacfunction.MethodsEightypatientswithSTEMIweredividedintothetreatmentgroupandthecontrolgroup.BasedonPCI-groupandnon-PCI,theplasmaNT-proBNPlevelsweremeasuredinthesepatientsinoneweeks、sixmonthsaftermyocar
5、dialinfarctionandinonedaybeforedelayedPCIandinthreedaysafterdelayedPCI,Leftventricularvolumeindees,ejectionfractionandleftventricularenddiastolicendvolumeindexesweremeasuredinoneweeks、sixmonthsaftermyocardialinfarctionandonedaybeforedelayedPCIineachgroup.ResultsThreedaysa
6、fterdelayedPCI,NT-proBNPinthePCIgroupdecreasedsingnificantly；sixmonthsafterSTEMbNT-proBNPinthePCIgroupwassingnificantlylowerthanthatinthenon-PCIgroup,leftventricularenddiastolicvolumeinnon-PCIgroupwassingnificantlylargerthaninthePCIgroup.ConclusionDelayedPCIforinfarctrela
7、tedarterywouldinhibitventricularenlargementbenefitingtotheheartfunction.【Keywords】DelayedPCINT-proBNPHeartfunctionN-末端腦鈉素原(N-terminalproBNP,NT-proBNP)來自腦鈉素前體(proBNP)o越來越多的資料證實(shí),NT-proBNP的應(yīng)用不僅限于診斷和篩查心功能不全，而且對(duì)急性心肌梗死(acutemyocardialinfarction,AMI)患者心肌梗死后左室重構(gòu)、左室功能、病死率的評(píng)估冇重要價(jià)值。
8、本文通過觀察急性ST段抬高型心肌梗死(acuteST-segmentelevationmyocardialinfarction，STEMI)患者延遲PCI術(shù)前及術(shù)后血漿N-末端腦鈉素原(NT-
