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《延遲PCI對(duì)急性ST段抬高型心肌梗死患者血漿N-末端腦鈉素原影響及臨床意義.doc》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在工程資料-天天文庫。
1、延遲PCI對(duì)急性ST段抬高型心肌梗死患者血漿N■末端腦鈉素原影響及臨床意義陳子國黃琦磊王光友（福建醫(yī)科大學(xué)附屬南平第一醫(yī)院心內(nèi)科福建南平353000）【中圖分類號(hào)】R542.2【文獻(xiàn)標(biāo)識(shí)碼]A【文章編號(hào)】1672-5085（2011）43-0011-03【摘要】目的研究急性ST段抬高型心肌梗死患者延遲PCI術(shù)前及術(shù)后血漿N?末端腦鈉素原水平變化，探討延遲PCI對(duì)心功能的影響。方法選擇住院治療的急性ST段抬高型心肌梗死患者80例，根據(jù)是否行延遲PCI術(shù)分為兩組，兩組患者均于心梗后1周、術(shù)前1天、術(shù)后3天、6個(gè)月檢測
2、血漿腦鈉素N端前體肽水平的變化，分別于心梗后1周、術(shù)前1天、術(shù)后3天、6個(gè)月做心臟超聲檢查,測定左室射血分?jǐn)?shù)及左室舒張末期容積，對(duì)比PCI組和非PCI組兩組患者心臟超聲和N?末端腦鈉素原的動(dòng)態(tài)變化。結(jié)果PCI組術(shù)后3天腦鈉素N端前體肽水平明顯下降（PV0.01）；6個(gè)月后PCI組的N?末端腦鈉素原明顯低于非PCI組（P<0.01）,PCI組的左室射血分?jǐn)?shù)值高于非PCI組（PV0.05）,非PCI組左室舒張末期容積明顯大于PCI組（PV0.05）。結(jié)論延遲PCI能改善急性心肌梗死患者的心功能?！娟P(guān)鍵詞】延遲經(jīng)皮冠狀
3、動(dòng)脈介入N?末端腦鈉素原心功能TheeffectofdelayedPCIonNT-proBNPandclinicalsign訐icanceinpatientswithacuteST-segmentelevationmyocardialinfaretion[Abstract]ObjectiveTostudychangesofplasmalevelofN-terminalproBNP（NT-proBNP）beforeandafterdelayedpercutaneouscoronaryintervention（PCI
4、）inthepatientswithacuteST-segmentelevationmyocardialinfarction（STEMI）,investigatetheeffectofdelayedPCIoncardiacfunction.MethodsEightypatientswithSTEMIweredividedintothetreatmentgroupandthecontrolgroup.BasedonPCI-groupandnon?PCI’theplasmaNT-proBNPlevelsweremea
5、suredinthesepatientsinoneweeks>sixmonthsaftermyocardialinfarctionandinonedaybeforedelayedPCIandinthreedaysafterdelayedPCI丄eftventricularvolumeindees,ejectionfractionandleftventricularenddiastolicendvolumeindexesweremeasuredinoneweeks、sixmonthsaftermyocardiali
6、nfarctionandonedaybeforedelayedPCIineachgroup?ResultsThreedaysafterdelayedPChNT-proBNPinthePCIgroupdecreasedsingnificantly；sixmonthsafterSTEMLNT-proBNPinthePCIgroupwassingnificantlylowerthanthatinthenon-PCIgroup,leftventricularenddiastolicvolumeinnon-PCIgroup
7、wassingn訐icantlylargerthaninthePCIgroup.ConclusionDelayedPCIforinfarctrelatedarterywouldinhibitventricularenlargementbenefitingtotheheartfunction.[Keywords]DelayedPCINT-proBNPHeartfunctionN?末端腦鈉素原(N-terminalproBNBNT-proBNP)來自腦鈉素前體(proBNP)o越來越多的資料證^NT-proBNP的應(yīng)
8、用不僅限于診斷和篩查心功能不全，而J4對(duì)急性心肌梗死(acutemyocardialinfarction,AMI)患者心肌梗死后左室重構(gòu)、左室功能、病死率的評(píng)估有重要價(jià)值。木文通過觀察急性ST段抬高型心肌梗死(acuteST-segmentelevationmyocardialinfarction,STEMI)患者延遲PCI術(shù)前及術(shù)后血漿N?末端腦鈉素原(NT?proBN
