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1、授予單位代碼10089學號或申請?zhí)?0153224中國圖書分類號R742.1HebeiMedicalUniversity碩士學位論文文文專業(yè)學位癲癇患者認知功能損害的特點、影響因素及其與血清IGF-1水平的相關性研究研究生：吳建坤導師：王維平教授專業(yè)：神經(jīng)病學二級學院：河北醫(yī)科大學第二醫(yī)院2018年3月目錄中文摘要······································································································1英文摘要···························
2、·························································2英文縮寫······························································································4研究論文癲癇患者認知功能損害的特點、影響因素及其與血清IGF-1水平的相關性研究前言·····························································································
3、···············5材料與方法····························································································6結果·································································································8附圖············································································
4、···········11附表················································································12討論··················································································16結論·······················································································22參考文獻··············
5、····································································22附錄·······················································································28綜述癲癇患者認知功能康復研究···································29致謝··············································································
6、···························39個人簡歷························································································40中中中文文文文摘摘摘摘要要要要癲癇患者認知功能損害的特點、、影響因素及其與血清、影響因素及其與血清IGF-1水平的相關性研究摘要目的：探討癲癇患者認知功能水平及其損害的特點，分析認知功能的影響因素,及其與血清胰島素樣生長因子-I（IGF-1）水平的相關性。方法：本研究記錄癲癇患者臨床資料、抗癲癇藥物（AEDs）使用情況及腦電圖結果等，采
7、用蒙特利爾認知評估量表（MoCA）對50例癲癇患者及30例健康者進行認知功能評定，采用酶聯(lián)免疫吸附試驗（ELISA）檢測血清IGF-1表達水平。結果：1.癲癇患者MoCA總分、視空間執(zhí)行、命名、記憶、注意力、語言、定向力得分、血清IGF-1表達水平均低于對照組（P＜0.05）。2.不同教育程度、腦電圖異常情況的癲癇患者MoCA評分差異有統(tǒng)計學意義（P＜0.05）。教育水平越高，認知評分越高；腦電圖存在癲癇樣異常放電，認知評分低。3.癲癇患者MoCA評分與病程呈負相關（P＜0.05）,與血清I
