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ID:32023070
大小:3.82 MB
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時間:2019-01-30
《頸動脈斑塊積分與冠狀動脈粥樣硬化病變嚴重程度的相關性-研究》由會員上傳分享,免費在線閱讀,更多相關內容在教育資源-天天文庫。
1、摘要冠狀動脈粥樣硬化性心臟病是一組以冠狀動脈粥樣硬化為主要病理基礎,并引起冠狀動脈管腔內斑塊形成,或因功能(如血管痙攣等)因素,導致管腔狹窄或阻塞,引起心肌缺血缺氧,最終導致心肌壞死的癥候群,嚴重威脅我國人民的身體健康和生活水平。有研究表明,頸動脈粥樣硬化與冠狀動脈粥樣硬化性心臟病及腦梗死等心腦血管事件之間存在密切聯系,因此,能否通過對頸動脈粥樣硬化程度的評價間接反應冠狀動脈的病變情況,是目前研究的熱點。目的探尋頸動脈粥樣硬化,特別是頸動脈斑塊相關參數與冠狀動脈粥樣硬化性心臟病嚴重程度之間的關系。方法選取207例經冠狀動脈造影確診為冠心病的患者,依
2、據造影結果的病變血管支數分為單支病變組、雙支病變組及多支病變組,收集其一般臨床資料及頸動脈超聲檢查結果,并計算反映頸動脈斑塊的Crouse積分和等級積分,以及反映冠狀動脈病變嚴重程度的Gensini積分和Leaman積分,并對兩者相關性進行比較。結果各組間性別比例、體重指數、總膽固醇、甘油三酯、低密度脂蛋白膽固醇、高密度脂蛋白膽固醇、吸煙等指標均無統計學差異,但平均年齡、糖尿病患者及斑塊檢出率方面,雙支病變組及多支病變組高于單支病變組(P3、ini積分及Leaman積分呈逐漸升高趨勢;Crouse積分與Gensini積分(嚴0.455,P<0.01)和Leaman積分(r=0.358,P<0.01)均呈正相關。不同性別間比較,女性患者中,Crouse積分僅與Gensini積分呈正相關(產O.343,P<0.05),與Leaman積分之間無明顯統計學相關性(產0.242,P>0.05),而男性患者中,Crouse積分與Gensini積分(嚴0.194,P>0.05)和Leaman積分(r=0.153,P>0.05)均未呈現明顯統計學相關性。結論頸動脈斑塊評分與冠狀動脈粥樣硬化嚴重程度存在4、相關性,頸動脈斑塊積分,如Crouse積分可以基本反映冠狀動脈粥樣硬化嚴重程度。不同性別間,女性患者頸動脈粥樣硬化程度與冠狀動脈粥樣硬化程度相關性較強。關鍵詞冠狀動脈疾病,頸動脈疾病,動脈粥樣硬化,超聲檢查AbstractCoronaryarterydiseaseisasyndromewhichbasedonatherosclerosis,thenleadingtoplaqueformationorspasm.Asitsprogression,stenosisorocclusionofcoronaryarteriesresultinhypoxiao5、fmyocardium,finallydevelopedintothemyocardialinfarctionandevendeath.Recently,severalstudiesimplicatedthatatherosclerosis,thebasisofcoronaryarterydiseases,isasystematicprocedureandthereWasarelevancebetweencarotidatherosclerosisandcoronaryatherosclerosis.Somanystudiesfocusonwhet6、hercarotidatherosclerosisCanbeagoodsurrogatemarkertocertificatetheseverityofcoronaryarterydisease.That’Swhatweareinterestedin.Purpose:Carotidultrasonographyisoneofthemostefficientmethodstoevaluateatherosclerosis.Thisstudyaimstoclarifytherelevancebetweencarotidplaqueandthesever7、ityofcoronaryarterydisease.Methods:Subjectswere207patientswhounderwentcoronaryangiographyanddiagnosedcoronaryheartdisease.Patientsweredividedintothreegroups,one-vesseldisease(1VD),two-vesseldisease(2VD)andthree-or-morevesseldisease(3VD)bythenumberofvesselsinvolved.Physicalfind8、ings,biochemistrydataandcarotidultrasonographicdata,likeCrous
3、ini積分及Leaman積分呈逐漸升高趨勢;Crouse積分與Gensini積分(嚴0.455,P<0.01)和Leaman積分(r=0.358,P<0.01)均呈正相關。不同性別間比較,女性患者中,Crouse積分僅與Gensini積分呈正相關(產O.343,P<0.05),與Leaman積分之間無明顯統計學相關性(產0.242,P>0.05),而男性患者中,Crouse積分與Gensini積分(嚴0.194,P>0.05)和Leaman積分(r=0.153,P>0.05)均未呈現明顯統計學相關性。結論頸動脈斑塊評分與冠狀動脈粥樣硬化嚴重程度存在
4、相關性,頸動脈斑塊積分,如Crouse積分可以基本反映冠狀動脈粥樣硬化嚴重程度。不同性別間,女性患者頸動脈粥樣硬化程度與冠狀動脈粥樣硬化程度相關性較強。關鍵詞冠狀動脈疾病,頸動脈疾病,動脈粥樣硬化,超聲檢查AbstractCoronaryarterydiseaseisasyndromewhichbasedonatherosclerosis,thenleadingtoplaqueformationorspasm.Asitsprogression,stenosisorocclusionofcoronaryarteriesresultinhypoxiao
5、fmyocardium,finallydevelopedintothemyocardialinfarctionandevendeath.Recently,severalstudiesimplicatedthatatherosclerosis,thebasisofcoronaryarterydiseases,isasystematicprocedureandthereWasarelevancebetweencarotidatherosclerosisandcoronaryatherosclerosis.Somanystudiesfocusonwhet
6、hercarotidatherosclerosisCanbeagoodsurrogatemarkertocertificatetheseverityofcoronaryarterydisease.That’Swhatweareinterestedin.Purpose:Carotidultrasonographyisoneofthemostefficientmethodstoevaluateatherosclerosis.Thisstudyaimstoclarifytherelevancebetweencarotidplaqueandthesever
7、ityofcoronaryarterydisease.Methods:Subjectswere207patientswhounderwentcoronaryangiographyanddiagnosedcoronaryheartdisease.Patientsweredividedintothreegroups,one-vesseldisease(1VD),two-vesseldisease(2VD)andthree-or-morevesseldisease(3VD)bythenumberofvesselsinvolved.Physicalfind
8、ings,biochemistrydataandcarotidultrasonographicdata,likeCrous
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