脊髓背角膠質(zhì)細(xì)胞在外周神經(jīng)損傷所致神經(jīng)病理性痛中的作用

脊髓背角膠質(zhì)細(xì)胞在外周神經(jīng)損傷所致神經(jīng)病理性痛中的作用

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時間:2019-02-17

脊髓背角膠質(zhì)細(xì)胞在外周神經(jīng)損傷所致神經(jīng)病理性痛中的作用_第1頁
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1、分類號密級國際十進(jìn)分類號(UDC)第四軍醫(yī)大學(xué)博士學(xué)位論文脊髓背角膠質(zhì)細(xì)胞在外周神經(jīng)損傷所致神經(jīng)病理性痛中的作用周揚(yáng)培養(yǎng)類別學(xué)歷研究生申請學(xué)位類型學(xué)術(shù)學(xué)位學(xué)科(領(lǐng)域)專業(yè)麻醉學(xué)指導(dǎo)教師徐禮鮮教授(主任醫(yī)師)指導(dǎo)教師單位口腔醫(yī)院麻醉科二O一二年五月獨(dú)創(chuàng)性聲明秉承學(xué)校嚴(yán)謹(jǐn)?shù)膶W(xué)風(fēng)與優(yōu)良的科學(xué)道德,本人聲明所呈交的論文是我個人在導(dǎo)師指導(dǎo)下進(jìn)行的研究工作及取得的研究成果。盡我所知,除了文中特別加以標(biāo)注和致謝的地方外,論文中不包含其他人已經(jīng)發(fā)表或撰寫過的研究成果,不包含本人或他人已申請學(xué)位或其他用途使用過的成果。與我一同工作的同志對本研究所做的任何貢獻(xiàn)均已在論文中作了明確的說明并表示了致謝。

2、申請學(xué)位論文與資料若有不實(shí)之處,本人承擔(dān)一切相關(guān)責(zé)任。論文作者簽名:日期:保護(hù)知識產(chǎn)權(quán)聲明本人完全了解第四軍醫(yī)大學(xué)有關(guān)保護(hù)知識產(chǎn)權(quán)的規(guī)定,即:研究生在校攻讀學(xué)位期間論文工作的知識產(chǎn)權(quán)單位屬第四軍醫(yī)大學(xué)。本人保證畢業(yè)離校后,發(fā)表論文或使用論文工作成果時署名單位仍然為第四軍醫(yī)大學(xué)。學(xué)校可以公布論文的全部或部分內(nèi)容(含電子版,保密內(nèi)容除外),可以采用影印,縮印或其他復(fù)制手段保存論文。學(xué)校有權(quán)允許論文被查閱和借閱,并在校園網(wǎng)上提供論文內(nèi)容的瀏覽和下載服務(wù)。同意學(xué)校將論文加入《中國優(yōu)秀博碩士學(xué)位論文全文數(shù)據(jù)庫》和編入《中國知識資源總庫》,同意按《中國優(yōu)秀博碩士學(xué)位論文全文數(shù)據(jù)庫出版章程》規(guī)

3、定享受相關(guān)權(quán)益。論文作者簽名:導(dǎo)師簽名:日期:第四軍醫(yī)大學(xué)博士學(xué)位論文脊髓背角膠質(zhì)細(xì)胞在外周神經(jīng)損傷所致神經(jīng)病理性痛中的作用研究生:周揚(yáng)學(xué)科專業(yè):麻醉學(xué)所在單位:第四軍醫(yī)大學(xué)口腔醫(yī)學(xué)院麻醉科導(dǎo)師:徐禮鮮教授(主任醫(yī)師)李云慶教授輔導(dǎo)教師:每曉鵬講師(主治醫(yī)師)資助基金項(xiàng)目:國家自然科學(xué)基金(30901400)關(guān)鍵詞:神經(jīng)病理性痛,脊神經(jīng)結(jié)扎,小膠質(zhì)細(xì)胞,星形膠質(zhì)細(xì)胞,慢性化,Toll樣受體3,氯胺酮,Wnt-3a,F(xiàn)rizzled-4,β-catenin中國人民解放軍第四軍醫(yī)大學(xué)2012年5月第四軍醫(yī)大學(xué)博士學(xué)位論文目錄縮略語表··························

4、·························································1中文摘要···················································································3ABSTRACT···············································································7前言·························································

5、·························11文獻(xiàn)回顧··················································································13正文··················································································23實(shí)驗(yàn)一脊髓背角小膠質(zhì)細(xì)胞TLR3參與氯胺酮治療神經(jīng)病理性痛的研究····························································

6、·······························231材料················································································231.1主要試劑·····································································231.2動物的準(zhǔn)備··································································241.3主要儀器··············

7、·······················································242方法················································································242.1鞘內(nèi)置管和給藥····························································242.2脊神經(jīng)結(jié)扎(SNL)模型的制備··········

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