資源描述：
《蘇拉明對肺腺癌小鼠移植瘤生長的影響及其機制》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、《癌癥》ChineseJournalofCancer,2008,27(4):359-363359·基礎(chǔ)研究·蘇拉明對肺腺癌小鼠移植瘤生長的影響及其機制賀兼斌111112,易高眾,楊凱,向志,謝茂峰,張平InhibitoryEffectsofSuraminonGrowthofTransplantedLungAdencarcinomainMiceandItsMechanisms111112HEJian-Bin,YIGao-Zhong,YANGKai,XIANGZhi,XIEMao-Feng,ZHANGPing[ABSTRACT]BACKGROUND&OBJECTIVE:Rece
2、ntstudyfoundthatsuramincouldinhibitthegrowthofmalignanttumors,butitsinvivoeffectonlungadenocarcinomahasseldombeenreported.Thisstudywastoinvestigatetheinhibitoryeffectsofsuraminonthegrowthandmetastasisoftransplantedlungadenocarcinomainmice,andexplorethemechanisms.1.懷化市第一人民醫(yī)院METHODS:Lungaden
3、ocarcinomaLA795cellsweretransplantedinto32呼吸內(nèi)科,T739mice.Thetumor-bearingmicewererandomizedintocontrolgroup,湖南懷化418000cisplatin(DDP)group,suramingroup,andcombination(suraminplusDDP)2.南華大學(xué)附屬第一醫(yī)院group;eachgroupcontained8mice.Differenttreatmentswereservedsince呼吸內(nèi)科,Day4aftertransplantation.Allm
4、icewerekilled24daysaftertransplantation.湖南衡陽421001Themetastatictumorfocionthelunginmicewerecounted.Theoccurrencerateoflungmetastasisandtheinhibitionrateofmetastaticfociwerecalculated.1.DepartmentofRespiratoryThevolumeandweightoftumorsweremeasured.TheexpressionofepidermalDiseases,growthfact
5、orreceptor(EGFR),P-selectinandproliferatingcellnuclearTheFirstPeople6sHospitalofantigen(PCNA)intumortissuesweredetectedbyimmunhistochemistry.HuaihuaCity,RESULTS:DDPandsuraminusedaloneorincombinationsignificantlyHuaihua,Hunan,418000,inhibitedthegrowthofLA795cellsinmice(P<0.05),withgrowthinh
6、ibitionP.R.Chinaratesof34.9%,23.8%and57.3%,respectively.Theoccurrencerateoflung2.DepartmentofRespiratorymetastasisandthenumberofmetastaticfocionlungsurfacewereDiseases,significantlylowerinsuramingroupandcombinationgroupthaninDDPTheFirstAffliliatedHospital,groupandcontrolgroup(P<0.05).Thepr
7、oteinlevelsofEGFRandP-selectinNanhuaUniversity,weresignificantlyhigherincontrolgroupthaninDDPgroup,suramingroup,Hengyang,Hunan,421001,andcombinationgroup(157.7±6.1vs.130.7±5.9,110.3±5.8,and89.2±P.R.China5.4,P<0.05;134.5±5.7vs.117.9±5.1,96.2±5.4,and78.3±4.5,P<0
