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1、·l194·MODERNONCOLOGY,Jun.2010,VO1.18,NO.6表達(dá)高度正相關(guān),具有一致性,共同表達(dá)不僅反映了骨肉瘤[4]JungST,MoonES,SeoHY,eta1.Expressionandsignificanceof內(nèi)微血管生成情況,也從某種程度反映了骨肉瘤的生長(zhǎng)、浸TGF—betaisoformandVEGFinostosarcoma[J].Orthopedics,潤(rùn)轉(zhuǎn)移的惡性潛能較大,可聯(lián)合作為評(píng)價(jià)骨肉瘤患者預(yù)后的2005,28(8):755.[5]GiatromanolakiA
2、,SivridisE,SimopoulosC,eta1.Hypoxiainduc。一項(xiàng)客觀指標(biāo)。iblefactorslalphaand2alphaareassociatedwithVEGFexpression【參考文獻(xiàn)】andangiogenesisingallbladdercarcinomas[J].SurgOncol,2006,[1]BrownNS,JonesA,F(xiàn)ujiyamaC,eta1.Thymidinephosphorylase94:242—247.inducescarcinomacelloxid
3、ativestressandpromotessecretionof[6]KobayashiT,KawaharaH,KoidoS,eta1.Significanceofthymidineangiogeni—efectors[J].CancerRes,2000,60(20):6298.phosphorylaseexpressioninstromalcellsaroundinvasivefrontof[2]SznurkowskaK,LenckowskiR,PopadiukS,eta1.Assessmentofrect
4、alcancer[J].Hepatogastroenterology,2008,55(88):2045—angiogenesisinchildrenosteosarcoma[J].MedWiekuRozwoj,2O48.2006,l0(3):737.(編校:田媛)[3]李海峰,阮狄克,王德利.VEGF在骨肉瘤組織中的表達(dá)及l(fā)晦床意義[J].中國(guó)矯形外科雜志,2004,12(9):689.唑來膦酸注射液治療惡性腫瘤骨轉(zhuǎn)移疼痛的臨床觀察李學(xué),李園,賈立群EficacyofzoledronicacidInjectio
5、nOfReliefofpainduetoosseousmetastasisLIXue,LIYuan,兒ALi—qunDepartmentofoncology,China—JapanFriendshipHospital,BeJtng100029,China.【Abstract】0bjective:ToevaluatetheeficacyandsafetyofzoledronicacidinjectiontorelievepainduetoosseoHsmetastasis.Methods:Atotalof80pa
6、tientswithosseousmetastasiswererandomizedtoinfuseintravenouslyeitherzoledronicacidinjection4mg(treatmentgroup)for15rainorpamidronateinjection60mg(controlgroup)for4h.Results:NRSoftreatmentgroupwaslower,thetimereachingtoCRoftreatmentgroupwasshorter(P<0.05),CR,
7、PRandRRoftwogroupsweresame.Conclusion:Theinjectivetimeofzoledronicacidinjectionisshorter,doseissmaller,effectisfaster.a(chǎn)ndhassatisfactorytolerationandsafety.【Keywords】zoledronicacidInjection;pamidronateinjection;metastaticbonepainModemOncology2010,18(06):1194
8、—1196【摘要】目的:評(píng)價(jià)唑來膦酸注射液治療腫瘤骨轉(zhuǎn)移疼痛的療效及安全性。方法:將8O例因惡性腫瘤骨轉(zhuǎn)移引起中度以上疼痛患者隨機(jī)分為兩組,研究組(45例)予唑來膦酸注射液4mg溶于100ml生理鹽水中靜脈滴注15min。對(duì)照組(35例)予帕米膦酸二鈉注射液60mg溶于500ml生理鹽水中靜脈滴注4h。研究期為14d。結(jié)果:兩組在治療后第14d的疼痛評(píng)分唑來膦酸優(yōu)于帕米膦酸二鈉(3.6