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1、中風(fēng)與神經(jīng)疾病雜志2011!旦箍鲞笠!塑·809·文章編號(hào)：1003-2754(2011)09-0809-04腦出血后遲發(fā)性腦水腫血漿sFas和sFasL水平分析王兆平，王文靜，王前友，潘健，孫一兵摘要：目的探討可溶性Fas(sFas)和可溶性Fas配體(sFasL)的變化與急性腦出血(ACH)后遲發(fā)性腦水腫的關(guān)系。方法ACH后遲發(fā)性腦水腫患者12例，其中男性9例；隨機(jī)選取同期A(yíng)CH無(wú)遲發(fā)性腦水腫組12例，其中男性8例；同期年齡和性別相匹配的12例健康體檢合格者作為對(duì)照組，其中男性8例。采用酶聯(lián)免疫吸附法(ELISA)法測(cè)定血漿sFas和sFasL濃度，比較各組之間sFas和s
2、FasL濃度差異。結(jié)果ACH后遲發(fā)性腦水腫組14d血漿sFas和sFasL水平明顯高于A(yíng)CH無(wú)遲發(fā)性腦水腫組和對(duì)照組(P<0．01)，ACH后遲發(fā)性腦水腫組較ACH無(wú)遲發(fā)性腦水腫組于發(fā)病7d后血漿sFas和sFasL水平下降速度緩慢，血漿sFasL水平稍有上升。結(jié)論sFas和sFasL可能參與腦出血后遲發(fā)性腦水腫的形成，動(dòng)態(tài)性檢測(cè)血漿sFas和sFasL水平，可對(duì)于發(fā)現(xiàn)潛在的ACH后遲發(fā)性腦水腫具有一定的意義。關(guān)鍵詞：腦出血；sFas；sFasL；遲發(fā)性腦水腫；細(xì)胞凋亡中圖分類(lèi)號(hào)：R743．34文獻(xiàn)標(biāo)識(shí)碼：APlasmalevelofsFasandsFasLinacutecer
3、ebralhemorrhagewithdelayedcerebraledemaWANGZhao-ping，WANGWen4ing，WANGQian—you，eta1．(DeptofNeurology，eaffiliatedProvincialHospitalofAnhuiMedicalUniversity，Hefei230001，China)Abstract：ObjectiveToinvestigatetherelationshipbetweenthechangesoftheplasmalevelsofsolubleFas(sFas)，solubleFas—ligand(sFa
4、sL)anddelayedcerebraledemafollowingacutecerebralhemorrhage(ACH)．MethodsOurstudyincluded12casesofACHwithdelayedcerebraledemapatients(male9)and12casesofACHwithoutdelayedcerebraledema(male8)and12casesoftheageandsexmatchedhealthysubjects(male8)．TheplasmalevelsofsFasandsFasLweremeasuredbyenzyme—l
5、inkedimmunosorbentassay(ELISA)methodinthesegroupsandthedifiereneeinthelevelsofsFasandsFasLwerecomparedamongeachgroups．ResultsThelevelsofserumsFasandsFasLat14dafteronsetinACHwithdelayedcerebraledemagroupweresignificantlyhigherthanthatoftheACHwithoutdelayedcerebrale—demaandcontrolgroups(P<0．01
6、)andthatinACHwithdelayedcerebraledemagroupwasslowrateofdeclineat7dafteronset．ThelevelsofserumsFasLinACHwithdelayedcerebraledemagroupwereincreasedslightly7dafteronset．Con-clusionThesFasandsFasLprobablytakerolesintheprocessofACHwithdelayedcerebraledemaandtheirdynamicitymaybeacertainsignificanc
7、eforidentifypotentialACHwithdelayedcerebraledema．Keywords：Intracerebralhemorrhage；sFas；sFasL；Delayedcerebraledema；Neuronapoptosis腦出血(ICH)是嚴(yán)重威脅人類(lèi)健康及生活質(zhì)配體(sFasL)水平動(dòng)態(tài)觀(guān)察，探討遲發(fā)性腦水腫與細(xì)量的常見(jiàn)疾病，其預(yù)后較差，發(fā)病30d內(nèi)的死亡率接胞凋亡的關(guān)系，為研究遲發(fā)性腦水腫的發(fā)生機(jī)制提近40％～50％¨1J，大部分的存活者會(huì)遺留明顯的神
