醫(yī)學(xué)論文-松齡血脈康膠囊對(duì)原發(fā)性高血壓患者動(dòng)態(tài)血壓相關(guān)指標(biāo)的影響：隨機(jī)單盲對(duì)照試驗(yàn)

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1、醫(yī)學(xué)論文-松齡血脈康膠囊對(duì)原發(fā)性高血壓患者動(dòng)態(tài)血壓相關(guān)指標(biāo)的影響：隨機(jī)單盲對(duì)照試驗(yàn)???????????????????????作者：付莉,毛振興,王靜,張靜,鄭太蓉,王勝蓮?【摘要】?在聯(lián)合使用鈣離子拮抗劑及血管緊張素受體拮抗劑的基礎(chǔ)上加用中成藥，觀察其對(duì)24h動(dòng)態(tài)血壓監(jiān)測(cè)相關(guān)指標(biāo)的影響，評(píng)價(jià)降壓效應(yīng)及降壓穩(wěn)定性。方法：將70例初診為原發(fā)性高血壓或有原發(fā)性高血壓病史但服藥無規(guī)律或未正規(guī)服藥，就診時(shí)血壓分級(jí)為2～3級(jí)的患者隨機(jī)分為常規(guī)降壓組（常規(guī)組）和常規(guī)降壓加松齡血脈康組（松齡血脈康組），每組各35例。常規(guī)

2、組口服左旋氨氯地平片2.5mg，聯(lián)合替米沙坦片40mg，1次/d。松齡血脈康組在常規(guī)組治療的基礎(chǔ)上加服松齡血脈康膠囊1.5g，3次/d。療程均為2周。治療前后分別進(jìn)行24h動(dòng)態(tài)血壓監(jiān)測(cè)，并進(jìn)行谷峰比值、平滑指數(shù)等指標(biāo)的計(jì)算和血壓晨峰的判定。結(jié)果：兩組治療后24h、白晝及夜間平均收縮壓和收縮壓負(fù)荷值均低于治療前（P＜0.05），常規(guī)降壓加松齡血脈康的降壓效果優(yōu)于常規(guī)降壓（P＜0.05）。常規(guī)降壓加松齡血脈康能降低舒張壓，而常規(guī)降壓對(duì)舒張壓的影響不明顯。常規(guī)降壓加松齡血脈康降壓的同時(shí)能減慢心率，常規(guī)降壓則對(duì)心率影

3、響不明顯。松齡血脈康組谷峰比值高于常規(guī)降壓組（P＜0.05），兩組平滑指數(shù)比較，差異無統(tǒng)計(jì)學(xué)意義。兩組治療后血壓晨峰現(xiàn)象均得到改善（P＜0.05），常規(guī)降壓加松齡血脈康對(duì)血壓晨峰現(xiàn)象的改善程度優(yōu)于常規(guī)降壓（P＜0.05）。結(jié)論：在聯(lián)合使用左旋氨氯地平片和替米沙坦片的基礎(chǔ)上加用中成藥松齡血脈康膠囊，能更有效地降低心率和血壓，特別是收縮壓和收縮壓負(fù)荷值，降壓效應(yīng)的平穩(wěn)性更高，維持時(shí)間更長(zhǎng)，還能有效控制血壓晨峰現(xiàn)象?！娟P(guān)鍵詞】?高血壓;血壓測(cè)定;隨機(jī)對(duì)照試驗(yàn);單盲法???Objective:Toexplorethe

4、effectsofWesternmedicineincludingCa2+channelantagonistandangiotensinreceptorantagonistcombinedwithSonglingXuemaikangCapsule(SXC),acompoundtraditionalChineseherbalmedicineforcalmingliverandsuppressingliveryang,onbloodpressureindexesderivedfrom24hourambulat

5、orybloodpressuremonitoring(ABPM),andtoevaluatetheeffectsandstabilityofSXCinloweringbloodpressure.???Methods:Seventypatientswithessentialhypertensionofgrade2orgrade3wererandomlyassignedtoroutinegroupandSXCgroup.Therewere35casesineachgroup.Thepatientsintherou

6、tinegroupwereadministeredwith2.5mglevoamlodipineand40mgtelmisartanoncedaily,and1.5gSXCwasadministeredorallytothepatientsintheSXCgroupthreetimesdailybesideslevoamlodipineandtelmisartantreatment.Theywerealltreatedfortwoweeks.TwentyfourhourABPM,troughtopeakr

7、atioandsmoothnessindexweremeasuredbeforeandafterthetreatment.???Results:Twentyfourhour,dayandnightaveragesystolicbloodpressure(SBP)and24hour,dayandnightSBPloadinthetwogroupswereloweredascomparedwithbeforetreatment(P＜0.05).TheeffectsofWesternmedicinecombi

8、nedwithSXConbloodpressuredepressionwerebetterthanthoseofWesternmedicine(P＜0.05).WesternmedicinecombinedwithSXChadasignificantinfluenceondiastolicbloodpressure(DBP)ascomparedwithWesternmedicine(P＜0.05).