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1、萬方數(shù)據中國臨床康復第9卷第77期2005.05.07出版chi聊卵如MmDf0,cfin婦f舶^n6以血耐jf0~肘Ⅱ步720D5%己9^,o,7比較豬去氧膽酸與牛磺熊去氧膽抗神經細胞缺氧缺糖再給氧損傷的作用☆張壯1,閏彥芳2,孫塑倫2,何麗云2,王碩仁1,朱陵群2,牛福玲北京中醫(yī)藥大學,1中醫(yī)內科學教育部重點實驗室;2東直門醫(yī)院中醫(yī)腦病研究室,北京市100700通訊作者:張壯☆,男,1970年生,黑龍江省哈爾濱市人,漢族,1998年中國中醫(yī)研究院畢業(yè),博士,副研究員,副主任醫(yī)師,主要從事腦保護中藥的藥效機制與效應成分的相互關系和中藥復方配伍的
2、科學依據。liyuebj@sohu.com中圖分類號:R743文獻標識碼:A文章編號:1671—5926(2005)17—0134—03收稿日期:2004—08—23修回日期:2005一03—28(04/sM/Yw)Protectived!fbctsofhyodeoxychoUcacidversustauroursodes-慨ycholic孔沁帆thei川uryind眥edbyhypo婦a/hypogIycemiaandr∞xyge船tionin恥rve∞Ilszhangzhuan91,YanYan.fan92,SunSu—Iun2.HeLj—y
3、un2,WangShuO—renl,ZhuLing—qun2.NiuFu—ling‘,1KeyLaboraloryofMjnislryofEducati咖,Inten】alMedicj玎eof7I’raditiona】ChjneseMedicine,BeijingUniversityofChineseMedicine,Beiiingl00700,China;2DepartmentofNeurology,DongzhimenHospital,Be巧ingUniVersityofChi—neseMedieine,Beiiing100700,China
4、Corr∞pondenceto:ZhangZhuang☆,M.D.,Associateresearcher,Associ—atechiefphysjcian,KeyLaboratnry“Minis£ry《Educa£i鯽,In£em止Medicineof1YaditionalChineseMedicine,BeiiingUniversityofChineseMedicine,Beiiing100700,Chinalivuebi@sohu.comR∞eived:2004一08—23Accepted:2005一03—28AbstI墨ctAIM:Tos
5、tudythepmtectiveefkctsofthemaincholicacid—likecomponentsofporcinegaUpowderhyodeoxycholicacidandbeargallpowdertaumur-sodesoxycholicacidontheinjuryinducedbyhypoxia/hypoglycemia肌dre01ygenationinnervecells.METHoDS:TheexDerimentwas6nishedintheInternalMedicineofTmditionalChineseMed
6、icine,BeiiingUniversityofChineseMedicinefromJuly2000toAugust2002.TIlehumanneumblastomawascultured,粕dmodelsofhvpoxia/hvpoglycemiawasestablishedwithEadesolutionofsodiumdithionatewithoutglucose.Themodelsweredividedrandomlyintocontrolgroup,hypoxia/hypogIycemiaandre01ygenationgrou
7、p,3.125,1.563,O.78l斗mol/Lhyodeoxycholicacidgroups,3.125,1.563,0.781斗m01/Ltauroursodesoxvcholicacid舯ups.ThecenularmortalitywasdetectedwitlltrvDanbluestain;theceUsurvivalratewasddtectedwitllMTTassay;thecellularlactatedehydrogenasereleaseratewasdetectedwithchromometry;thecellula
8、rnecrosisrateandthecellularapoptosisratewereobservedwithnuorescencem