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1、LessonOneIntroductiontoBiochemicalEngineeringBiochemicalengineeringaddressesabroadrangeofcriticalproblemsinthemanufacturingofmetabolites,pharmaceauticals,therapeuticproteinsandotherapplicationsofmicrobialandanimalcellbiotechnology.Biochemicalengineeringprovi
2、desstudentswithskillstoapplychemicalengineeringprinciplestobioreactordesign,downstreamprocessingandoverallbioprocessoptimization.Theaimistoprovidechemicalengineerswithabasicunderstandingofthefundermentalprocessengineeringproblemsspecifictobiochemicalprocesse
3、s.Alsotoprovideaninsightintotheceativityrequiredinbioreactordesigh.ResearchactiveitiesincludeprojectsextendingtheChemicalEngineeringparadigmofTransportandKineticstobiologicalsystem,aswellasprojectsexploringdevelopmentsintheLifeScienceforpurposeofprovidingbio
4、logicalsolutionstolong-stangdingengineeringproblems.Theoverallobjectivesaretodevelopfundermentalunderstandingofthephysicalandchemical/biologicalprocessesinvolvedinthebiosynthesisandtransportofaproductmolecule,andtoapplythisknowledgetotheimprovementofthecorre
5、spondingproductionandseparation/purificationoperations.Thereareprojectsingeneticandmetabolicengineering;newproteinexpressionsystems;proteintrafficking,post-translationalmodificationandsecretion;in-vivoandin-vitroproteinfolding;interplaybetweenenvironmentandc
6、ellularphysiologyandfunction;bioreactordesign,operationsandcontrol;intracellularandextracellularmonitoringmethods;biocatalysisandbioreactors;mermbraneandchromatographicoperations;reversemicellarandtwo-phaseseparationsystems;protein-proteinandprotein-surfacei
7、nteraction;andmodelling;expertsystemsandartificialintelligenceapplicaionstoproblemsofupstreamanddownstreambiotechnologicaloperations?TheinterdisciplinarynatureofbiotechnologyisprobablybestreflectedintheprogramonMetabolicEngineering.Metabolicengineeringisdefi
8、nedasthetargetedimprovementofcellularpropertiesandfunctionthroughthemodificationofaspecificbiochemicalreactionwiththeuseofrecombinantDNAmethods.Rationalpathwaymodificationeffectedthroughmetaboli
