資源描述：
《Myb轉(zhuǎn)錄因子.ppt》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、MybTranscriptionFactorLiuPeiyuMYBtranscriptionfactorsinplantsMorethan20yearsago,thefirstgeneencodingatranscriptionfactorinplantswasidentified——COLORED1(C1)Adecadeago,theArabidopsisgenomesequencewaspublished,whichprovidedthefirstcomprehensivedescriptionandc
2、lassificationofplantMYBgenes.Inrencentyears,thefunctionsofMYBproteinshavebeeninvestigatedinnumerousplantspecies.StructureandevolutionMYBproteinsarecharacterizedbyahighlyconservedDNA-bindingdomain:theMYBdomain（consistsofuptofourimperfectaminoacidsequencerep
3、eats(R)ofabout52aminoacids,eachformingthreea–helices).MYBproteinscanbedividedintodifferentclassesdependingonthenumberofadjacentrepeats(one,two,threeorfour)IncontrasttothehighlyconservedMYBdomain,theotherregionsofR2R3-MYBproteinsarehighlyvariable.Basedonthe
4、conservationoftheDNAbindingdomainandofaminoacidmotifsintheCterminaldomains,R2R3-MYBproteinshavebeendividedintosubgroups.DiversityoffunctionsNumerousR2R3-MYBproteinshavebeencharacterizedbygeneticapproachesandfoundtobeinvolvedinthecontrolofplant-specificproc
5、essesincluding:(i)primaryandsecondarymetabolism(ii)cellfateandidentity(iii)developmentalprocesses(iv)responsestobioticandabioticstressesRegulationofMYBfunctionsMYBgenesaretargetstobothmicroRNAs(miRNAs)andtransacting,silencingRNAs(ta-siRNAs).Post-translatio
6、nalmodificationsandprotein–proteininteractionscansignificantlyimpacttheregulatoryactivityofMYBtranscriptionfactors.ThetranscriptionalactivityofsomeR2R3-MYBfactorsisdependentinvivoonprotein–proteininteractions.PhosphorylationisimportantindeterminingMYBprote
7、inactivity.RedoxcontrolisthoughttoinfluenceMYBproteinactivitybecauseofthepresenceofapairofconservedCysresidues,fourresiduesapart,intheR2-MYBmotifofmost3R-andR2R3-MYBproteinsTheactivityofmanytranscriptionalregulatorsismodulatedbyconjugationwithubiquitinorth
8、esmallubiquitinrelatedmodifierThemodulationoftranscriptionfactoractivitybysumoylationcanoccurbymultiplemechanismsincludingsubcellularlocalization,DNA-bindingactivityordecreasingtheactivityofaTAD,asdescribedfo
