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1、VETERINARYi~'~e'''':MEDICINEELS[:NIERPreventiveVeterinaryMedicine21(1994)65-74PorcinerespiratorycoronavirusspreadinCatalunya,Spain,apreviouslyinfection-freeareaMargaritaMartina'*,JordiCasaP,IgnacioLanzau,PedroRubiou,PedroCdrmenesb"PatologialnfecciosaiEp
2、idemiologia,DepartamentdePatologiaiProducci6,4nimals,U.A.B.,08193-Bellaterra,SpainbEnfermedadeslnfecciosasyEpizootiologia,DepartamentodePatologiaAnimal(SanidadAnimal),UniversidaddeLeon,24007-Le6n,Spain(Accepted2February1994)AbstractAretrospectivestudyof
3、serafromsevencommercialpigherdswasconductedfromMay1985toJuly1989,showingthatantibodiesagainstPorcineRespiratoryCoronavirus(PRCV)werefirstdetectedinSpaininSeptember1986.During1991astratifiedsam-plingofbreedingherdswasconductedtoestablishprevalencetoPRCVo
4、rTransmissibleGastroenteritisVirus(TGEV)infectionsinCatalunya(northeastSpain).Anantibody-captureELISAwasusedforPRCV-and/orTGEV-antibodies,whileacompetitiveinhi-bitionELISAtestedforTGEV-specificantibodies.Thisstudyrevealed91.1%positiveseraand96.7%positiv
5、efarmstoPRCVand/orTGEVwithagradualincreaseinprevalenceduring1991,whichwasmorenoticeableinsmallherds.Ofthetotal569herdstested,65.2%werepositiveonlytoPRCV,8.6%werepositivetoTGEVand22.8%hadmixedinfections.Thefirstappearanceofantibodiescoincidedwithlargeimp
6、ortationoffeederpigsfromBelgiumandHolland.ThisprevalenceismuchhigherthanpreviouslyreportedinotherregionsofSpain.I.IntroductionDuringthelastdecade,anewporcinecoronaviruswithtropismfortherespi-ratorytractappearedinEurope.Theappearanceofahighprevalenceofan
7、tibod-iestoTransmissibleGastroenteritisVirus(TGEV)withoutsignsofdiarrheawasfirstreportedinBelgianherdsin1984(Pensaertetal.,1986),followedshortly*Correspondingauthor.0167-5877/94/$07.00?1994ElsevierScienceB.V.AllrightsreservedSSDIOI67-5877(94)OO358-P66M.
8、Martinetal./Preventive[~terinar)'Medicine21(1994)65-74bymostswinefarmsinWesternEuropeancountries.TheTGE-likevirusisolatewasdesignatedTGE-likemutant(TLM-83)andnamedPorcineRespiratoryCoronavirus(PRCV).Antibodiesinducedbythisviruswe
