他汀類藥物對(duì)急性心肌梗死患者pci術(shù)后無復(fù)流的影響

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1、中國心血管病研究2010年8月第8卷第8期ChineseJournalofCardiovascularResearch，August2010，V01．8，No-8．561．他汀類藥物對(duì)急性心肌梗死患者PCI術(shù)后無復(fù)流的影響Effectsofpre—-treatmentofstatinsonno-reflowphenomenoninAMIpatientsaftersuccessfulprimaryangioplasty丁超李俊峽趙玉英張莉汝磊生孫家安彭育紅作者單位：050082河北省石家莊市，解放軍自求恩國際和平醫(yī)院心血管內(nèi)科通訊作者：丁超，E-mail：dingch2001@so

2、hu．com【摘要】目的探討急性心肌梗死(AMI)患者經(jīng)皮冠狀動(dòng)脈介入治療(PCI)術(shù)前應(yīng)用他汀類藥物對(duì)無復(fù)流及主要心臟不良事件(MACE)的影響。方法首次sT抬高型AMI發(fā)病12h內(nèi)行直接PCI治療的136例連續(xù)人院患者，按照術(shù)前是否服用他汀類藥物分為他汀治療組(40例)和非他汀治療組(96例)。觀察PCI術(shù)后無復(fù)流的發(fā)生情況。結(jié)果他汀組PCI術(shù)后無復(fù)流發(fā)生率明顯低于非他汀組(12．5％比34．3％，P

3、CI術(shù)后1個(gè)月他汀組MACE發(fā)生率明顯低于非他汀治療組(12．5％比31_3％，P<0．01)。結(jié)論P(yáng)CI術(shù)前應(yīng)用他汀類藥物可明顯降低PCI術(shù)后無復(fù)流發(fā)生率，減少M(fèi)ACE發(fā)生，改善預(yù)后?！娟P(guān)鍵詞】他汀；急性心肌梗死；經(jīng)皮冠脈介入治療；無復(fù)流doi：10．39690．issn．1672-5301．2010．08．001中圖分類號(hào)17,542．2；R541．4文獻(xiàn)標(biāo)識(shí)碼A文章編號(hào)1672—5301(2010)08-0561-03Efectsofpre-treatmentofstatinsonno-reflowphenomenoninAMIpatientsaftersuccessful

4、primaryangioplastyDINGChao，LIJun—xia，ZHAOYu—ying，eta1．DepartmentofCardiology，BethuneInternationalPeaceHospitalofpLA，Shijiazhuang050082，ChinaCorrespondingauthor：DINGChao，E-mail：dingch2001@sohu．com[Abstract]ObjectiveToevaluatetheefectofpre—．treatmentwithstatinonthedevelopmentoftheno——reflowandt

5、heincidenceofmainadvemecardiacevents(MACE)inpatientswhounderwentSUCCeSSfU]primarypercutanouscoronaryintervention(PCI)foracutemyocardialinfarction(AMI)．MethodsAtotalof136consecutiveAMIpatientsundergoingPC1weredividedintotwogroupsaccordingtowhetherusingstatinsornot．ResultsThe40patientsreceiving

6、long-termstatintreatmentbeforeadmissionhadlowerincidenceoftheno—reflowthanthosewithoutit(12．5％vs34_3％，P<0．01)．Logisticanalysesshowedthatabsenceofpre—treatmentwithstatinwasanindependentpredictorofno—reflow(RR3．56，95％C／1．59—4．58，P<0．05)．TheyalsoshowedlowerincidenceofMACE(12．5％VS31-3％。P<0．01)ins

7、tatingroupat1monthslater．CondusionPre—treatmentthstatincouldreducetheincidenceoftheno-reflowandMACEafterprimaryPCIinAMIpatients．[Keywords]Statins；Acutemyocardialinfarction；Percutanouscoronaryintervention；No—reflow急性心肌梗死(AMI)后梗死相關(guān)血管的早期、reflowp