尼妥珠單抗聯(lián)合調(diào)強放療及 GP 方案治療局部復(fù)發(fā)鼻咽癌的臨床觀察.pdf

《尼妥珠單抗聯(lián)合調(diào)強放療及 GP 方案治療局部復(fù)發(fā)鼻咽癌的臨床觀察.pdf》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。

1、·lO86·醫(yī)學臨床研究2014年6月第31卷第6期

2、n!!!』：!!論著尼妥珠單抗聯(lián)合調(diào)強放療及GP方案治療局部復(fù)發(fā)鼻咽癌的臨床觀察郭戈楊羅英楊曉琳李字(湖南省腫瘤醫(yī)院放療科，湖南長沙410006)[摘要]【目的】探討尼妥珠單抗聯(lián)合調(diào)強放療及吉西他濱加順鉑(GP)方案治療局部復(fù)發(fā)鼻咽癌的療效?！痉椒ā繉⒈驹?1例局部復(fù)發(fā)鼻咽癌患者隨機分為觀察組(35例)和對照組(36例)，兩組均采用調(diào)強放療和吉西他濱加順鉑方案化療，觀察組每周一次放療前靜脈滴注尼妥珠單抗100mg，共6～7次。觀察比較兩組患者治療療效。【結(jié)果】觀察組治療結(jié)束3個月后原發(fā)灶完全緩解率及治療1年及2年后局部控

3、制率分別為65．7、91．4及82．9，而對照組為41．7、72．2及61．1，兩組相比較差異有顯著性(P<0．05)。觀察組治療后1年及2年無遠處轉(zhuǎn)移生存率分別為88．6及77．1，而對照組為75．0及66．6，觀察組要高于對照組，但兩組相比較差異無顯著性(P>O．05)。兩組的近期及遠期不良反應(yīng)發(fā)生率無統(tǒng)計學差異(P>0．05)?！窘Y(jié)論】尼妥珠單抗聯(lián)合調(diào)強放療及GP方案能提高局部復(fù)發(fā)鼻咽癌的完全緩解率及局部控制率。[關(guān)鍵詞]鼻咽腫瘤／藥物療法；鼻咽腫瘤／放射療法；順鉑／投藥和劑量Clinical0bservationofNimotuzumabCombinedwithIM

4、RTandGPRegimenintheTreatmentofLocallyRecurrentNasopharyngealCarcinomaGUOGe—yang，LUOYing，YANGXiao—lin，etⅡZ(DepartmentofRadiology，HunanTumorHospital，Changsha410006，China)[Abstract][Objective]Toexploretheefficacyofnimotuzumabcombinedwithintensity-modulatedradiothera—py(IMRT)andGPregimen(gemci

5、tabinepluscisplatin)inthetreatmentoflocallyrecurrentnasopharyngealcarci—noma(NPC)．[MethodslAtotalof71patientswithlocallyrecurrentNPCinourhospitalwererandomlydividedintoobservationgroup(7l一36)andcontrolgroup(n=36)．AllpatientsreceivedIMRTandGPregimen(gemcit—abinepluscisplatin)．Theobservation

6、groupwasintravenouslyadministerednimotuzumab100mgweeklyfor6～7weeksbeforeradiotherapy．TheefficacyoftWOgroupswasobservedandcompared．[ResultslThecompletere—sponse(CR)ofprimarylesionat3monthsaftertreatmentandlocalcontrolrateat1and2yearsaftertreatmentintheobservationgroupwere65．7，91．4and82．9res

7、pectively，whilethoseinthecontrolgroupwere41．7，72．2and61．1respectively，andtherewassignificantdifferencebetweentwogroups(P

8、6，respectively)，buttherewasnosignificantdifferencebetweentwogroups(P>0．05)．Therewasnosignificantdifferenceintheinci—deuceofshort-termandlong-termtoxicsideeffectsbetweentwogroups．[ConelusionlNimotuzumabcombinedwithIMRTandGPregimencanimprovetheCRrateandlocalcont