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1、·45··循證醫(yī)學(xué)·同步放化療與單純放療治療局部晚期宮頸癌的Meta分析張蕾唐杰張娟娟【摘要】目的系統(tǒng)評(píng)價(jià)同步放化療和單純放療治療宮頸癌的有效性。方法計(jì)算機(jī)檢索CochraneLibrary、PubMed、Embase、中國生物醫(yī)學(xué)文獻(xiàn)數(shù)據(jù)庫、中文科技期刊全文數(shù)據(jù)庫、中國期刊全文數(shù)據(jù)庫。全面查找有關(guān)同步放化療和單純放療治療宮頸癌的隨機(jī)對(duì)照試驗(yàn),兩名評(píng)價(jià)者單獨(dú)評(píng)價(jià)納入研究的方法學(xué)質(zhì)量并提取資料,用RevMan5.1軟件進(jìn)行Meta分析。結(jié)果共納入文獻(xiàn)lO篇,Meta分析結(jié)果顯示:同步放化療組和單純放療組比較,兩組在總生存率方面差異有統(tǒng)計(jì)學(xué)意義(艘=1.17,
2、95%C/:1.1O~1.24),兩組在總有效率方面差異有統(tǒng)計(jì)學(xué)意義(礎(chǔ)=1.24,95%C/:1.16~1.33)。結(jié)論當(dāng)前臨床證據(jù)表明與單純放療相比,同步放化療可提高局部晚期宮頸癌患者的有效率和生存率?!娟P(guān)鍵詞】宮頸腫瘤;放射療法;藥物療法;Meta分析MetaanalysisofchemotherapycombinationwithradiotherapyversusradiotherapyaloneinthetreatmentoflocallyadvancedcervicalcarcinomaZhangLei,餾Jie,ZhangJuanjuan.
3、DepartmentofGynecology,ShenzhenUniversityLuohuHospital(TheFifthPeopleHospita,ofShenzhen),Shenzhen518001,ChinaCorrespondingauthor:Tang,lie,Email:tangfieyisheng@l63.corn[Abstract]ObjecfiveTosystematicallyassesstheeficacyofchemotherapycombinationwithradiotherapyversusradiotherapyalon
4、einthetreatmentoflocallyadvancedcervicalcarcinomaMethodsWesearchedEmbase,Pubmed,theCochraneLibrary,V,CNKI,Chinesebiomedicineliteraturedatabaseforrandomizedcontrolledtrialscomparingchemotherapycombinationwithradiotherapyversusradiotherapyaloneinthetreatmentoflocallyadvancedcervical
5、carcinoma.Tworeviewersindependentlyassessedthequalityofincludedstudiesandextracteddata.WeanalyzedthedatausingReviewManager(version5.1).ResultsTenrandomizedcontrolledtrialstotalingwereincluded.Metaanalysisshowedthattherewasstatisticaldifferencebetweentheradiotherapyalonegroupandche
6、motherapycombinationwithradiotherapygroupinoverallsurvivalrate碾;1.17,95%CI:1.10-1.24)andoverallresponserate(艘=1.24,95%CI:1.16-1.33).ConclusionCurrentevidenceindicatedthatcomparedwithradiotherapyalone,chemotherapycombinationnlradiotherapycouldimproveoverallsurvivalrate(RR1.17,95%1.
7、10-1.24)andoverallresponserateforpatientwithlocallyadvancedcervicalcarcinoma.[Keywords]Uterinecervicalneoplasms;Radiotherapy;Dragtherapy;Meta-analysis宮頸癌是發(fā)病率和死亡率僅次于乳腺癌的最紀(jì)90年代美國國立癌癥研究所將含順鉑方案同步常見女性惡性腫瘤。宮頸癌主要的治療方法是手術(shù)放化療作為治療中晚期宮頸癌的標(biāo)準(zhǔn)治療模式[11。和放療,早期以手術(shù)治療為主,中晚期大多采用放單純放射治療對(duì)于體積較小的腫瘤有較高的治愈射
8、治療。目前的國際治療趨勢(shì)強(qiáng)調(diào)綜合治療,20世率,對(duì)體積較大者很難通