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1、第2O卷第18期中國實(shí)驗(yàn)方劑學(xué)雜志Vo1.20.No.182014年9月ChineseJournalofExperimentalTraditionalMedicalFormulaeSep.,2014中西醫(yī)結(jié)合治療幽門螺旋桿菌陽性消化性潰瘍44例敖麗麗h,李曄(1.固原市原州區(qū)人民醫(yī)院,寧夏固原756000;2.北京天壇醫(yī)院,北京100006)[摘要]目的:觀察清幽I號(hào)方聯(lián)合四聯(lián)療法對(duì)消化性潰瘍(PU)幽門螺桿菌(Hp)的根除率及對(duì)潰瘍復(fù)發(fā)的影響。方法:88例Pu患者隨機(jī)按數(shù)字法分為對(duì)照組和觀察組各44例。對(duì)照組服用奧美拉唑,2
2、0nlg/次,2次/d;枸櫞酸鉍鉀片,2粒/次,2次/d;阿莫西林膠囊,1g/次,2次/d;克拉霉索,500Ing/次,2次/d。療程為14d。14d后再采用法莫替丁,20mg/次,1次/d,再治療14d。觀察組在對(duì)照組治療的基礎(chǔ)上加用清幽I號(hào)方,1劑/d,常規(guī)水煎分2次服用,共28d。記錄治療后Hp清除情況;采用組織學(xué)再生黏膜成熟度評(píng)價(jià)潰瘍愈合質(zhì)量;進(jìn)行1年隨訪觀察復(fù)發(fā)情況。結(jié)果:觀察組總體療效有效率為97.73%,對(duì)照組為81.82%,觀察組優(yōu)于對(duì)照組(P<0.05);觀察組Hp清除率為90.9%,對(duì)照組為75%,觀察組H
3、p清除率高于對(duì)照組(P<0.05);觀察組再生黏膜組織學(xué)成熟度評(píng)價(jià)優(yōu)于對(duì)照組(P<0.05);對(duì)照組13例復(fù)發(fā),復(fù)發(fā)率45.16%,觀察組8例復(fù)發(fā),復(fù)發(fā)率20%,觀察組復(fù)發(fā)率低于對(duì)照組(P<0.05);觀察組平均復(fù)發(fā)時(shí)間(10.1±1.93)個(gè)月長于對(duì)照組的(8.74-1.84)個(gè)月(P<0.05)。結(jié)論:在常規(guī)四聯(lián)療法的基礎(chǔ)上加服清幽I號(hào)方能提高Hp清除率,提高潰瘍愈合質(zhì)量,減少/延緩Pu復(fù)發(fā),提高臨床療效。[關(guān)鍵詞]消化性潰瘍;幽門螺桿菌感染;四聯(lián)療法;清幽I號(hào)方;幽門螺桿菌清除率;潰瘍愈合質(zhì)量[中圖分類號(hào)]R287[文獻(xiàn)
4、標(biāo)識(shí)碼]A[文章編號(hào)]1005—9903(2014)18—0196—04[doi]10.13422/j.cnki.syfjx.2014180196TreatmentofCombinationofTraditionalChineseandWesternMedicinein44CaseswithHelicobacterPyloriPositivePepticUlcerAOLi—li.,J,l‘e(1.ThePeople'sHospitalofGuyuanCityYuanzhouDistrict,Guyuan756000,China
5、;2.TiantanHospitalofBeijing,Belting100006,China)[Abstract]Objective:Observetheeradicationrateofhelicobacterpylori(Hp)ofpepticulcer(PU)andulcerrecurrenceinpatientstreatedwithQingyou1stdecoctioncombinedwithquadrupletherapy.Method:Eighty—eightpatientswererandomlydivide
6、dintocontrolgroupandobservationgroup(44cases,respectively).Patientsincontrolgroupreceivedoraladministrationofomeprazole(20mgeachtime),bismuthpotassiumcitratetablets(2pieceseachtime)amoxicillincapsule(1geachtime)andclarithromycin(500mgeachtime)twiceaday.After14daysof
7、treatmentFamotidinewouldcontinuetobeusedforatadosageof20mgeachtime(onceaday)foranother14days.Basedonthetreatmentofcontrolgroup,patientsinobservationgroupaddeddecoctmedicinalherbs—Qingyou1stdecoction,(1doesperday,takenattwotimes)foranother28days.ClearanceofHpwasrecor
8、dedaftertreatment.Qualityofulcerhealingwasevaluatedwithhistologicregenerativemucosalmaturity.One-yearfollow-upwasmadetoobserveulcerrecuren