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《國(guó)產(chǎn)凍干麻疹一流行性腮腺炎聯(lián)合減毒活疫苗免疫效果研究.pdf》由會(huì)員上傳分享,免費(fèi)在線閱讀,更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫(kù)。
1、·48·QRNALOFVACCINESANDIMMUNIZATIONVo1.18No.12012國(guó)產(chǎn)凍干麻疹一流行性腮腺炎聯(lián)合減毒活疫苗免疫效果研究王志勇,肖奇友,張淑君,陳海平,宋繼萍,李振海,廖國(guó)樂(lè),何德彪,陳斌,張寒麗,李放軍,黃銘華,高立冬,李俊華(1.湖南省疾病預(yù)防控制中心,長(zhǎng)沙410005;2.北京生物制品研究所,北京100024:3.永興縣疾病預(yù)防控制中心,湖南永興423300;4.永順縣疾病預(yù)防控制中心,湖南永順416700)摘要:目的對(duì)市售的凍干麻疹.流行性腮腺炎聯(lián)合減毒活疫苗(MeaslesandMumDsComb
2、inedArtenuatedLiveVaccine,F(xiàn)reeze—dried;MMV—Fd)的免疫效果進(jìn)行監(jiān)測(cè)和評(píng)價(jià)。方法用隨機(jī)整群抽樣方法,抽取永興、永順縣5070名3~49歲兒童,其中2474名兒童接種MMV·Fd(觀察組),2596名接種凍干水痘減毒活疫苗(對(duì)照組),觀察90名兒童免疫前、后血清抗體水平及兩年的流行病學(xué)效果,采用統(tǒng)計(jì)產(chǎn)品與服務(wù)解決方案(StafsticalProductandServiceSolutionsSPSS)13.0進(jìn)行統(tǒng)計(jì)學(xué)分析。結(jié)果MMV-Fd對(duì)流行性腮腺炎的保護(hù)率為92.28%;免疫前抗體陰性組(<
3、l:2)陽(yáng)轉(zhuǎn)率為85.71%,陽(yáng)性組(≥1:2)抗體≥4倍增長(zhǎng)率為76.81%,差異有統(tǒng)計(jì)學(xué)意義(=79.014,P<0.01):免疫后抗體幾何平均滴度陽(yáng)性組(≥l:2)明顯高于陰性組(<1:2),差異有統(tǒng)汁學(xué)意義(f=6.117,P<0.01)。結(jié)論MMV.Fd對(duì)流行性腮腺炎有較好的免疫效果。關(guān)鍵詞:國(guó)產(chǎn)凍干麻疹-流行性腮腺炎聯(lián)合減毒活疫苗;免疫效果中圖分類號(hào):R186;R512.1文獻(xiàn)標(biāo)識(shí)碼:A文章編號(hào):1006—916X(2012)01—0048.03ImmunologicalEffectofDomesticMeaslesand
4、MumpsCombinedAttenuatedLiveVaccine(Freeze·dried)WANGZhi—yong,XIAOQi-you,ZHANGShu,jun,eta1.(HunanProvincialCenterforDiseaseControlandPre∞ention,Changsha410005,Hunan,China)Abstract:ObjectiVeTomakesurveillanceandassessmentonimmunologicalefectofdomesticmeaslesandmumpscombin
5、edattenuatedlivevaccine(freeze.ed)(MMV-Fd).MethodRandomclustersamplingwasappliedtoanumberof5,070childrenaged3-9yearsinYongxinandYongshuncountyofhunanprovince,Amongthem,2,474wasimmunizedwithMMV-Fd(observationgroup),andtheother2,596childrenadministeredwithvaricellaattenua
6、tedlivevaccine(freeze—dried)(controlgroup).Theserumantibioticlevelof90childrenbeforeandaftervaccination,epidemiologicalefectinlater2yearswasstudiedaswel1.Adoptstatisticalproductandservicessolutions13.0tomakestatisticalanalysis.ResulteprotectionrateofMMV—Fdagainstepidemi
7、ologicalmumpswas92.28%;theconversionrateforthegroupwithnegativeantibioticlevelbeforevaccination(<1:2)is85.71%,f0rthepositivegroup(≥1:2),≥4timesincreaseofantibodyis76.81%,thediferencehasstatisticalsignificance(=79.014,P8、oup(≥l:2)isobviouslyhigherthannegativegroup(