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1、第28卷第5期川I北醫(yī)學(xué)院學(xué)報(bào)Vo1.28.No.54182013年10月JOURNALOFNORTHSICHUANMEDICALCOLLEGE0ct.2Ol3doi:10.3969/j.issn.1005—3697.2013.05.002...影像醫(yī)學(xué)研究專題·論著...原發(fā)性肝癌TACE后血清VEGF水平與CT表現(xiàn)的研究任勇軍一,楊林一,繆南東,鄧進(jìn),胡曉(1.川北醫(yī)學(xué)院附屬醫(yī)院放射介入室;2.醫(yī)學(xué)影像四JiI省重點(diǎn)實(shí)驗(yàn)室,四川南充637000)【摘要】目的:探討原發(fā)性肝癌(primaryhepa
2、ticcarcinoma,PHC)在介入治療(TACE)后血清血管內(nèi)皮生長(zhǎng)因子(vascularendothelialgrowthfactor,VEGF)水平與cT表現(xiàn)之間的關(guān)系。方法:PHC患者32例,男性28例,女性4例,年齡15~72歲,平均年齡(49.53±13.10)歲。所有病例均行一次TACE治療。采集TACE前1d、術(shù)后3Od清晨空腹肘靜脈血樣標(biāo)本,分離血清,采用ELISA方法檢測(cè)其血清VEGF水平。收集術(shù)前1周內(nèi)、術(shù)后30d上腹部cT影像學(xué)表現(xiàn)。采用SPSS13.0軟件進(jìn)行統(tǒng)計(jì)分析。結(jié)
3、果:TACE術(shù)前1d、術(shù)后30dVEGF水平分別為(520.99±320.61)pg/mL、(3l6.37±240.67)pg/mL,P=0.000。TACE術(shù)前1周內(nèi)、術(shù)后30d腫瘤大小分別為(8.28±3.61)cnl、(7.68±3.42)cm,P=0.Oll。無(wú)論術(shù)前還是術(shù)后VEGF水平與腫瘤大小呈正相關(guān)。術(shù)前有轉(zhuǎn)移病灶、染色不均病灶的VEGF水平高于無(wú)轉(zhuǎn)移病灶、染色均一病灶。術(shù)后單發(fā)病灶、無(wú)轉(zhuǎn)移病灶、染色均一病灶VEGF低于多發(fā)病灶、有轉(zhuǎn)移病灶、染色不均病灶。無(wú)論術(shù)前還是術(shù)后右肝內(nèi)病灶與左肝
4、內(nèi)病灶、有包膜病灶與無(wú)包膜病灶VEGF水平無(wú)差異。結(jié)論:無(wú)論術(shù)前還是術(shù)后,血清VEGF水平與腫瘤大小呈正相關(guān),與病灶部位、包膜無(wú)關(guān)。TACE后,血清VEGF水平與腫瘤轉(zhuǎn)移、染色相關(guān)?!娟P(guān)鍵詞】原發(fā)性肝癌;血管內(nèi)皮生長(zhǎng)因子;化學(xué)治療;栓塞;計(jì)算機(jī)斷層掃描【文章編號(hào)】1005.3697(2013)05—0418-05【中圖分類號(hào)】R735.7【文獻(xiàn)標(biāo)識(shí)碼】AStudyonlevelofserumVEGFandCTimaginginPHCafterTACERENYong—jun‘。,YANGLin一,MIA
5、ONan—dong,DENG—Jin,HUXiao’2(1.DepartmentofRadiology,AffiliatedHospitalofNorthSiehuanMedicalCollege:2.SichuanKeyLaboratoryofMedicalImaging.Nan-chong637000,Sichuan,China)【Abstract】Objective:Tostudytherelationbetweenthelevelofserumvascularendothelialgrowth
6、factor(VEGF)andCTimaginginprimaryhepaticcarcinoma(PHC)aftertranscatheterarterialchemoembolization(TACE).Methods:32patientsofPHCwereana—lyzed,including28malecasesand4femalecases.Theagesrangefrom15~72yearsold,andthemeanageis(49.53±13.10).Allcasesunderwent
7、TACEonce.Theearlymorningfastingulnarveinbloodsamplewasgatheredonthe1daybeforeTACEandonthe30dayafterTACErespectively.Theserumwasisolated.TheVEGFlevelwasdetectedbyusingELISA.Collectthedataofepigastri·amCTimagingoneweekbeforeTACEandonthe30dayafterTACE.Thec
8、orrelationwasanalyzedwithSPSS13.0software.Re-suits:ThelevelofVEGFonthe1daybeforeTACEandonthe30thdayafterTACEwere(520.99±320.61)pg/mLand(316.37±240.67)pg/mL,P=0.000.ThesizeoftumorinoneweekbeforeTACEandoilthe30thdayafterTACEwere(8.