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1、現(xiàn)代腫瘤醫(yī)學(xué)2015年2月第23卷第4期MODERNONCOLOGY，F(xiàn)eb．2015，VOL．23，NO．04·461·．．．頭頸腫瘤．．．扁桃體鱗癌中HPV感染與EGFR、VEGF表達(dá)的相關(guān)性研究費(fèi)繼敏，TimothyADobbins。，DeannaJones，CSoonLee，ChristineLoo，JonathanClark，BarbaraRoseThecorrelationofHPVinfectionwiththeexpressionofepidermalgrowthfactorrecep
2、tor(EGFR)andvascularendothelialgrowthfactor(VEGF)insquamouscellcarcinomasofthetonsiIFeiJimin1,2,1rim0thyADobbins3,DeannaJones。，CSoonLee，ChristineLoo5,6,jonathanClark2,BarbaraRose，DepartmentofHeadandNeckSurgery，theAfiliatedHospitalofKunmingMedicalCollege
3、，YunnanKunming650018，China；TheSydneyHeadandNeckCancerInstitute，SydneyCancerCentre，RoyalPrinceAlfredHospital，SydneyNSW2050，Australia；IntegratedCancerResearchGroup，UNSWCancerResearchCentre，SydneyNSW2050，Australia；4DepartmentofInfectiousDiseasesandImmunolo
4、—gY，UniversityofSydney，SydneyNSW2050，Australia；DisciplineofPathology，SchoolofMedicine，UniversityofWesternSydney，SydneyNSW2050，Australia；。DepartmentofAnatomicalPathology，LiverpoolHospital，SydneyNSW2050，Australia．【Abstract】Objective：Tostudytherelationship
5、betweenhumanpapillomavirus(HPV)infectionandtheexpres—sionofvascularendothelialgrowthfactor(VEGF)，epidermalgrowthfactor(EGFR)in85squamouscellcarcinomasofthetonsil(tonsillarSCCs)．Toinvestigatetheirsignificanceintheoncogenesisoftonsillarcancer．Methods：HPVs
6、tatuswasdeterminedbyHPVmultiplexreal—timepolymerasechainreaction(MT—PCR)．ExpressionofVEGFandEGFRinHPV(+)andHPV(一)groupwasassessedbysemiquantitativeimmunohistochemistry．Results：Theinfec—tionrateofHPVintonsillarSCCswas49．4％(42／85)．TheinfectionrateofHPV一16
7、was90．5％(38／42)inallpositivespecimenswassignificantlyhigherthanotherHPVtypes．TheexpressionofEGFRinHPV(一)groupwassignificantlyhigherthanthatinHPV(+)group(P<0．O1)．TheexpressionofVEGFhadnosignificantdifferencebetweenHPV(+)groupandHPV(一)group．Therewerenoass
8、ociationsbetweenVEGFandEGFRexpression，gender，age，TNMstageorhistologygrade．Conclusion：HPVinfectionhassignificantcorrelationwiththeoncogenesisoftonsillarSCCs．InHPV—positivetonsillarSCCs，HPVgenemaychangeEGFRexpression．【Keywords】tons
