資源描述：
《布美他尼抑制脊神經(jīng)元鈉鉀氯聯(lián)合轉(zhuǎn)運(yùn)蛋白1的功能實(shí)現(xiàn)鎮(zhèn)痛.doc》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在教育資源-天天文庫(kù)。
1、布美他尼抑制脊神經(jīng)元鈉鉀氯聯(lián)合轉(zhuǎn)運(yùn)蛋白1的功能實(shí)現(xiàn)鎮(zhèn)痛以往研究結(jié)果提示，鈉鉀氯聯(lián)合轉(zhuǎn)運(yùn)蛋白1和鉀氯聯(lián)合轉(zhuǎn)運(yùn)蛋白2，參與脊髓水平的疼痛傳導(dǎo)調(diào)控，可通過(guò)調(diào)節(jié)疼痛通路神經(jīng)元的氯離子濃度影響神經(jīng)元興奮性和疼痛敏化。中國(guó)南方醫(yī)科大學(xué)珠江醫(yī)院何雁冰博士所在團(tuán)隊(duì)發(fā)現(xiàn)，足底切割損傷后大鼠脊髓神經(jīng)元鈉鉀氯聯(lián)合轉(zhuǎn)運(yùn)蛋白1表達(dá)上調(diào)，鉀氯聯(lián)合轉(zhuǎn)運(yùn)蛋白2表達(dá)下調(diào)。作者推測(cè)，鞘內(nèi)布美他尼可能通過(guò)抑制脊神經(jīng)元鈉鉀氯聯(lián)合轉(zhuǎn)運(yùn)蛋白1的功能從而發(fā)揮對(duì)切割痛的鎮(zhèn)痛效應(yīng)。文章發(fā)表在《中國(guó)神經(jīng)再生研究（英文版）》雜志2014年5月第10期。免疫熒光染色顯示，大鼠足底切開(kāi)后鉀氯聯(lián)合轉(zhuǎn)運(yùn)蛋白2在腰4-5節(jié)段脊髓同
2、側(cè)背角深層表達(dá)減少Article:"Analgesiceffectofintrathecalbumetanideisaccompaniedbychangesinspinalsodium-potassium-chlorideco-transporter1andpotassium-chlorideco-transporter2expressioninaratmodelofincisionalpain,"byYanbingHe1,2,ShiyuanXu1,JunjieHuang2,QingjuanGong2(1DepartmentofAnesthesiology,Zhuji
3、angHospital,SouthernMedicalUniversity,Guangzhou,GuangdongProvince,China;2DepartmentofAnesthesiologyandPainMedicine,theSecondAffiliatedHospitalofGuangzhouMedicalUniversity,Guangzhou,GuangdongProvince,China)HeYB,XuSY,HuangJJ,GongQJ.Analgesiceffectofintrathecalbumetanideisaccompaniedbychan
4、gesinspinalsodium-potassium-chlorideco-transporter1andpotassium-chlorideco-transporter2expressioninaratmodelofincisionalpain.NeuralRegenRes.2014;9(10):1055-1062.欲獲更多資訊：NeuralRegenResIntrathecalbumetanidehasanalgesiceffectsthroughinhibitionofNKCC1Accumulatingevidencehasdemonstratedthatth
5、esodium-potassium-chlorideco-transporter1(NKCC1)andpotassium-chlorideco-transporter2(KCC2)havearoleinthemodulationofpaintransmissionatthespinallevelthroughchlorideregulationinthepainpathwayandbyeffectingneuronalexcitabilityandpainsensitization.Dr.YanbingHeZhujiangHospital,SouthernMedica
6、lUniversity,ChinaandhisteamfoundthatintrathecalbumetanidecouldincreaseNKCC1expressionanddecreaseKCC2expressioninspinalcordneuronsofratswithincisionalpain.TheauthorspresumedthatintrathecalbumetanidehasanalgesiceffectsonincisionalpainthroughinhibitionofNKCC1.ThispaperwaspublishedinNeuralR
7、egenerationResearch(Vol.9,No.10,2014).Immunofluorescentstainingrevealsthatpotassium-chlorideco-transporter2expressiondecreasesinthedeeplaminaeofipsilateraldorsalhornofL4-5spinalcorafterincision.Article:"Analgesiceffectofintrathecalbumetanideisaccompaniedbychangesinspinalsodium-
