gebp11多功能磁性納米探針對動脈斑塊及腫瘤血管新生的多模態(tài)分子影像研究

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1、分類號R541.4第四軍醫(yī)大學(xué)UDC616.1TheFourthMilitaryMedicalUniversity密級公開博士學(xué)位論文GEBP11多功能磁性納米探針對動脈斑塊及腫瘤血管新生的多模態(tài)分子影像研究蘇濤培養(yǎng)類別全日制學(xué)位類型學(xué)術(shù)學(xué)位一級學(xué)科(專業(yè)類)臨床醫(yī)學(xué)二級學(xué)科(專業(yè))內(nèi)科學(xué)（心血管?。┭芯糠较蛐难芊肿佑跋裱芯恐笇?dǎo)教師曹豐教授（主任醫(yī)師）培養(yǎng)單位西京醫(yī)院心內(nèi)科二O一五年十一月獨創(chuàng)性聲明秉承學(xué)校嚴(yán)謹(jǐn)?shù)膶W(xué)風(fēng)與優(yōu)良的科學(xué)道德，本人聲明所呈交的論文是我個人在導(dǎo)師指導(dǎo)下進(jìn)行的研究工作及取得的研究成果。盡我所知，除了文中特別加以標(biāo)注和致謝的地方外，論文中不包含其他人已經(jīng)發(fā)表或

2、撰寫過的研究成果，不包含本人或他人已申請學(xué)位或其他用途使用過的成果。與我一同工作的同志對本研究所做的任何貢獻(xiàn)均已在論文中作了明確的說明并表示了致謝。申請學(xué)位論文與資料若有不實之處，本人承擔(dān)一切相關(guān)責(zé)任。論文作者簽名：日期：保護知識產(chǎn)權(quán)聲明本人完全了解第四軍醫(yī)大學(xué)有關(guān)保護知識產(chǎn)權(quán)的規(guī)定，即：研究生在校攻讀學(xué)位期間論文工作的知識產(chǎn)權(quán)單位為第四軍醫(yī)大學(xué)。本人保證畢業(yè)離校后，發(fā)表論文等使用本論文工作成果時第一署名單位仍然為第四軍醫(yī)大學(xué)。學(xué)校可以公布論文的全部或部分內(nèi)容（含電子版，保密內(nèi)容除外），可以采用影印，縮印或其他復(fù)制手段保存論文；學(xué)校有權(quán)允許論文被查閱和借閱，并在校園網(wǎng)上提供論文內(nèi)

3、容的瀏覽和下載服務(wù)。同意學(xué)校將論文加入《中國優(yōu)秀博碩士學(xué)位論文全文數(shù)據(jù)庫》和編入《中國知識資源總庫》等，并可瀏覽和下載，同時享受《中國優(yōu)秀博碩士學(xué)位論文全文數(shù)據(jù)庫出版章程》規(guī)定的相關(guān)權(quán)益。論文作者簽名：導(dǎo)師簽名：日期：第四軍醫(yī)大學(xué)博士學(xué)位論文目錄縮略語表······························································································1中文摘要···································································

4、···························3ABSTRACT··························································································8前言·····························································································13文獻(xiàn)回顧·································································

5、····························14正文·····························································································32第一部分··························································································32GEBP11多功能磁性納米探針的制備和表征··············································321

6、材料···························································································322方法···························································································353結(jié)果···························································································424討論···

7、························································································48第二部分··························································································51Cy5.5-GEBP11-DMSA-MNPS探針對胃癌荷瘤裸鼠腫瘤血管新生的多模態(tài)成像··511材料······