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1、分類號R541.4第四軍醫(yī)大學UDC616.1TheFourthMilitaryMedicalUniversity密級公開博士學位論文GEBP11多功能磁性納米探針對動脈斑塊及腫瘤血管新生的多模態(tài)分子影像研究蘇濤培養(yǎng)類別全日制學位類型學術(shù)學位一級學科(專業(yè)類)臨床醫(yī)學二級學科(專業(yè))內(nèi)科學（心血管病）研究方向心血管分子影像研究指導教師曹豐教授（主任醫(yī)師）培養(yǎng)單位西京醫(yī)院心內(nèi)科二O一五年十一月獨創(chuàng)性聲明秉承學校嚴謹?shù)膶W風與優(yōu)良的科學道德，本人聲明所呈交的論文是我個人在導師指導下進行的研究工作及取得的研究成果。盡我所知，除了文中特別加以標注和致謝的地方外，論文中不包含其他人已經(jīng)發(fā)表或
2、撰寫過的研究成果，不包含本人或他人已申請學位或其他用途使用過的成果。與我一同工作的同志對本研究所做的任何貢獻均已在論文中作了明確的說明并表示了致謝。申請學位論文與資料若有不實之處，本人承擔一切相關(guān)責任。論文作者簽名：日期：保護知識產(chǎn)權(quán)聲明本人完全了解第四軍醫(yī)大學有關(guān)保護知識產(chǎn)權(quán)的規(guī)定，即：研究生在校攻讀學位期間論文工作的知識產(chǎn)權(quán)單位為第四軍醫(yī)大學。本人保證畢業(yè)離校后，發(fā)表論文等使用本論文工作成果時第一署名單位仍然為第四軍醫(yī)大學。學校可以公布論文的全部或部分內(nèi)容（含電子版，保密內(nèi)容除外），可以采用影印，縮印或其他復制手段保存論文；學校有權(quán)允許論文被查閱和借閱，并在校園網(wǎng)上提供論文內(nèi)
3、容的瀏覽和下載服務。同意學校將論文加入《中國優(yōu)秀博碩士學位論文全文數(shù)據(jù)庫》和編入《中國知識資源總庫》等，并可瀏覽和下載，同時享受《中國優(yōu)秀博碩士學位論文全文數(shù)據(jù)庫出版章程》規(guī)定的相關(guān)權(quán)益。論文作者簽名：導師簽名：日期：第四軍醫(yī)大學博士學位論文目錄縮略語表······························································································1中文摘要···································································
4、···························3ABSTRACT··························································································8前言·····························································································13文獻回顧·································································
5、····························14正文·····························································································32第一部分··························································································32GEBP11多功能磁性納米探針的制備和表征··············································321
6、材料···························································································322方法···························································································353結(jié)果···························································································424討論···
7、························································································48第二部分··························································································51Cy5.5-GEBP11-DMSA-MNPS探針對胃癌荷瘤裸鼠腫瘤血管新生的多模態(tài)成像··511材料······
