單側(cè)黑質(zhì)紋狀體通路損毀改變腹側(cè)蒼白球的神經(jīng)活動(dòng)

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1、單側(cè)黑質(zhì)紋狀體通路損毀改變腹側(cè)蒼白球的神經(jīng)活動(dòng)作者：張巧俊，楊慧麗，顏虹，藺雪梅，向莉，劉健【摘要】　　目的觀察單側(cè)黑質(zhì)紋狀體通路損毀對(duì)大鼠腹側(cè)蒼白球(ventralpallidum,VP)神經(jīng)元電活動(dòng)的影響。方法采用在體細(xì)胞外記錄方法研究正常大鼠和帕金森病(Parkinsonsdisease,PD)大鼠VP神經(jīng)元放電頻率和放電形式的變化。結(jié)果對(duì)照組大鼠VP神經(jīng)元的平均放電頻率為(16.1±1.2)Hz(n=41)；2周和4周PD組大鼠VP神經(jīng)元的平均放電頻率分別是(9.3±0.8)Hz(n=43)和(8.6±1.0)Hz(n=47)，與對(duì)照組相比，V

2、P神經(jīng)元的平均放電頻率顯著減低(P均<0.001)，但兩PD模型組之間VP神經(jīng)元的平均放電頻率無明顯差異(P>0.05)。在對(duì)照組大鼠，規(guī)則放電的神經(jīng)元占44%(18/41)，不規(guī)則放電的神經(jīng)元占52%(21/41)，爆發(fā)式放電的神經(jīng)元僅占4%(2/41)；在2周和4周PD模型組大鼠，具有規(guī)則、不規(guī)則和爆發(fā)式放電的VP神經(jīng)元的百分比分別為14%(6/43)、47%(20/43)、39%(17/43)和17%(8/47)、49%(23/47)、34%(16/47)，2周和4周PD組大鼠VP中爆發(fā)式放電的神經(jīng)元明顯多于對(duì)照組(P均<0.01

3、)，而兩PD模型組之間VP神經(jīng)元的放電形式未見顯著性差異(P>0.05)。結(jié)論單側(cè)黑質(zhì)紋狀體通路損毀誘發(fā)大鼠VP神經(jīng)元的放電頻率降低，具有爆發(fā)式放電的神經(jīng)元增多，這種變化可能與伏核VP的抑制性神經(jīng)傳遞增強(qiáng)有關(guān)。14【關(guān)鍵詞】腹側(cè)蒼白球；帕金森??；電生理學(xué)；大鼠　　ABSTRACT:ObjectiveToinvestigatethechangesinneuronalactivityoftheratventralpallidum(VP)followingunilaterallesionofthenigroatriatalpathway.Methods

4、ThechangesinthefiringfrequencyandfiringpatternofVPneuronswereexaminedwithextracellularrecordingmethodsincontrolandParkinsonsdisease(PD)rats.ResultsTheresultsshowedthatthemeanfiringfrequencyofVPneuronsincontrolratswas(16.1±1.2)Hz(n=41).InPDrats,themeanfiringfrequencyofVPneuronsaf

5、terunilaterallesionofthenigroatriatalpathwayatweek2and4was(9.3±0.8)Hz(n=43)and(8.6±1.0)Hz(n=47),respectively.ThemeanfiringfrequencyofVPneuronsofPDratsatweek2and4wassignificantlydecreasedwhencomparedtothatofcontrolrats(allP<0.001).However,therewasnosignificantdifferenceinthemea

6、nfiringfrequencyofVPneuronsofPDratsatweek2and4(P>0.05).Concerningthefiringpattern,44%(18/41)ofVPneuronsfiredregularly,52%(21/41)exhibitedirregularityand4%firedinburstsincontrolrats.InPDrats,14%(6/43)ofVPneuronsfiredregularly,47%(20/43)irregularlyand39%inburstsatweek2;1417%(8/4

7、7)ofVPneuronsfiredregularly,49%(23/47)irregularlyand34%(16/47)inburstsatweek4,respectively.ThepercentageofPDratsneuronfiringinburstsatweek2and4wassignificantlyhigherthanthatincontrolrats(allP<0.01),butthedifferenceinPDratsfiringpatternbetweenweek2and4didnotreachasignificantl

8、evel(P>0.05).ConclusionUnilaterallesi